The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease
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Multifaceted Role of Sialylation in Prion DiseasesPrion strains and amyloid polymorphism influence phenotypic variationChanges in retinal function and morphology are early clinical signs of disease in cattle with bovine spongiform encephalopathyPrion pathogenesis in the absence of NLRP3/ASC inflammasomesEfficient uptake and dissemination of scrapie prion protein by astrocytes and fibroblasts from adult hamster brainEvidence that bank vole PrP is a universal acceptor for prionsDe novo generation of prion strainsBiochemical properties of highly neuroinvasive prion strainsRelationships between PrPSc stability and incubation time for United States scrapie isolates in a natural host systemDefining the conformational features of anchorless, poorly neuroinvasive prionsSpontaneous variants of the [RNQ+] prion in yeast demonstrate the extensive conformational diversity possible with prion proteinsAnalysis of Conformational Stability of Abnormal Prion Protein Aggregates across the Spectrum of Creutzfeldt-Jakob Disease PrionsNLRP3 Inflammasome in Neurological Diseases, from Functions to TherapiesIs the prevalent human prion protein 129M/V mutation a living fossil from a Paleolithic panzootic superprion pandemic?Prion formation, but not clearance, is supported by protein misfolding cyclic amplification.Biochemical characterization of prion strains in bank volesHigh-resolution structure of infectious prion protein: the final frontierDistinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice.Relationship between conformational stability and amplification efficiency of prions.Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during protein misfolding cyclic amplificationSmall protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain.Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.Epigenetic dominance of prion conformers.An enzymatic treatment of soil-bound prions effectively inhibits replication.Tracking protein aggregate interactions.Insights into prion biology: integrating a protein misfolding pathway with its cellular environment.Structural determinants of phenotypic diversity and replication rate of human prions.In vitro generation of high-titer prionsPrion Strain Differences in Accumulation of PrPSc on Neurons and Glia Are Associated with Similar Expression Profiles of Neuroinflammatory Genes: Comparison of Three Prion StrainsA new mechanism for transmissible prion diseasesHost Determinants of Prion Strain Diversity Independent of Prion Protein Genotype.Stabilization of a prion strain of synthetic origin requires multiple serial passagesDeposition pattern and subcellular distribution of disease-associated prion protein in cerebellar organotypic slice cultures infected with scrapie.Sialylation of the prion protein glycans controls prion replication rate and glycoform ratioPrPSc formation and clearance as determinants of prion tropism.Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins.Fast and ultrasensitive method for quantitating prion infectivity titre.Protein misfolding cyclic amplification of prions.Selective amplification of classical and atypical prions using modified protein misfolding cyclic amplification.
P2860
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P2860
The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The strain-encoded relationshi ...... e incubation period of disease
@ast
The strain-encoded relationshi ...... e incubation period of disease
@en
The strain-encoded relationshi ...... e incubation period of disease
@nl
type
label
The strain-encoded relationshi ...... e incubation period of disease
@ast
The strain-encoded relationshi ...... e incubation period of disease
@en
The strain-encoded relationshi ...... e incubation period of disease
@nl
prefLabel
The strain-encoded relationshi ...... e incubation period of disease
@ast
The strain-encoded relationshi ...... e incubation period of disease
@en
The strain-encoded relationshi ...... e incubation period of disease
@nl
P2860
P50
P3181
P1433
P1476
The strain-encoded relationshi ...... e incubation period of disease
@en
P2093
Charles R Schutt
Ronald A Shikiya
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1001317
P407
P577
2011-03-01T00:00:00Z