The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity
about
The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's diseaseForkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop.Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington's DiseaseHuntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathwayA new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall musclesAMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease.Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis.Network analysis of human post-mortem microarrays reveals novel genes, microRNAs, and mechanistic scenarios of potential importance in fighting huntington's disease.Role of Wnt Signaling in Central Nervous System Injury.Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells.Neuroprotective and regenerative roles of intranasal Wnt-3a Administration after focal ischemic stroke in mice.The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms.Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment Epithelium.Keeping Neurons Young and Foxy: FoxOs Promote Neuronal Plasticity.Revolution of Alzheimer Precision Neurology Passageway of Systems Biology and Neurophysiology.Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathwaysBMP- and neuropilin 1-mediated motor axon navigation relies on spastin alternative translation
P2860
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P2860
The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity
description
2014 nî lūn-bûn
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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The Wnt receptor Ryk reduces n ...... utant huntingtin pathogenicity
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The Wnt receptor Ryk reduces n ...... utant huntingtin pathogenicity
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The Wnt receptor Ryk reduces n ...... utant huntingtin pathogenicity
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type
label
The Wnt receptor Ryk reduces n ...... utant huntingtin pathogenicity
@ast
The Wnt receptor Ryk reduces n ...... utant huntingtin pathogenicity
@en
The Wnt receptor Ryk reduces n ...... utant huntingtin pathogenicity
@nl
prefLabel
The Wnt receptor Ryk reduces n ...... utant huntingtin pathogenicity
@ast
The Wnt receptor Ryk reduces n ...... utant huntingtin pathogenicity
@en
The Wnt receptor Ryk reduces n ...... utant huntingtin pathogenicity
@nl
P2093
P2860
P50
P3181
P1433
P1476
The Wnt receptor Ryk reduces n ...... utant huntingtin pathogenicity
@en
P2093
Anne Louise
Anne-Marie Orfila
Cendrine Tourette
Christina K Edgerly
Francesca Farina
J Alex Parker
Jessica Voisin
Jungmok Lyu
Karen Smith
P2860
P304
P3181
P356
10.1371/JOURNAL.PBIO.1001895
P407
P577
2014-06-01T00:00:00Z