PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
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The Structural Architecture of an Infectious Mammalian Prion Using Electron CryomicroscopySynthetic prions with novel strain-specified propertiesIntraperitoneal Infection of Wild-Type Mice with Synthetically Generated Mammalian PrionRelationships between PrPSc stability and incubation time for United States scrapie isolates in a natural host systemPrion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuICThe structure of the infectious prion protein: experimental data and molecular models.Gingerol prevents prion protein-mediated neuronal toxicity by regulating HIF prolyl hydroxylase 2 and prion protein.Uptake and degradation of protease-sensitive and -resistant forms of abnormal human prion protein aggregates by human astrocytes.Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.Aggregation of MBP in chronic demyelination.A Neuronal Culture System to Detect Prion Synaptotoxicity.Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.Cellular prion protein: from physiology to pathology.Prions, proteinase K and infectivity.Strain-dependent profile of misfolded prion protein aggregates.Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo.Changes in prion replication environment cause prion strain mutationInfectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions.Soluble oligomers are sufficient for transmission of a yeast prion but do not confer phenotype.The extent of protease resistance of misfolded prion protein is highly dependent on the salt concentrationPrP Knockout Cells Expressing Transmembrane PrP Resist Prion InfectionDiscontools: Identifying gaps in controlling bovine spongiform encephalopathy.Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway.Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice.Isolation of Exosomes and Microvesicles from Cell Culture Systems to Study Prion Transmission.Cofactor molecules induce structural transformation during infectious prion formation.The roles of the conserved tyrosine in the β2-α2 loop of the prion protein.Applying the tools of chemistry (mass spectrometry and covalent modification by small molecule reagents) to the detection of prions and the study of their structure.What Is Our Current Understanding of PrPSc-Associated Neurotoxicity and Its Molecular Underpinnings?Prion infectivity is encoded exclusively within the structure of proteinase K-resistant fragments of synthetically generated recombinant PrPSc.Overexpression of quality control proteins reduces prion conversion in prion-infected cellsPrion acute synaptotoxicity is largely driven by protease-resistant PrPSc species
P2860
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P2860
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
@ast
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
@en
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
@nl
type
label
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
@ast
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
@en
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
@nl
prefLabel
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
@ast
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
@en
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
@nl
P2093
P2860
P50
P3181
P1433
P1476
PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP
@en
P2093
Adriana Ramos
Christina J Sigurdson
Elizabeth M Antaki
Ester Vázquez-Fernández
Irina Dynin
Jesús R Requena
Melissa L Erickson
Miguel A Pastrana
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1002547
P407
P577
2012-03-01T00:00:00Z