Purification and Characterization of West Nile Virus Nucleoside Triphosphatase (NTPase)/Helicase: Evidence for Dissociation of the NTPase and Helicase Activities of the Enzyme
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Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNAMutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication.Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing.Structure of the Dengue Virus Helicase/Nucleoside Triphosphatase Catalytic Domain at a Resolution of 2.4 ACharacterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme.Complementation analysis of the flavivirus Kunjin NS3 and NS5 proteins defines the minimal regions essential for formation of a replication complex and shows a requirement of NS3 in cis for virus assembly.Structure-Based Mutational Analysis of the NS3 Helicase from Dengue VirusMolecular and Functional Analyses of Kunjin Virus Infectious cDNA Clones Demonstrate the Essential Roles for NS2A in Virus Assembly and for a Nonconservative Residue in NS3 in RNA ReplicationDe Novo Synthesis of Negative-Strand RNA by Dengue Virus RNA-Dependent RNA Polymerase In Vitro: Nucleotide, Primer, and Template ParametersThe Two-component NS2B-NS3 Proteinase Represses DNA Unwinding Activity of the West Nile Virus NS3 HelicasePotential High-Throughput Assay for Screening Inhibitors of West Nile Virus ReplicationAn analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-β-d-ribofuranosideCyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 ProteinEffects of detergents on the West Nile virus protease activityThe global ecology and epidemiology of West Nile virusEnergetics of RNA binding by the West Nile virus RNA triphosphatase.Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug.Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis.Helicases as antiviral drug targets.Understanding helicases as a means of virus control.West Nile virus drug discovery.Flavivirus RNA synthesis in vitroAn Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection.Inhibition of dengue virus through suppression of host pyrimidine biosynthesisStructural and functional parameters of the flaviviral protease: a promising antiviral drug target.Synthesis and biological activity of 1H-benzotriazole and 1H-benzimidazole analogues--inhibitors of the NTpase/helicase of HCV and of some related Flaviviridae.Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses.Direct fluorometric measurement of hepatitis C virus helicase activity.The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases.NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus.UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.The importance of the Q motif in the ATPase activity of a viral helicase.Requirements for West Nile virus (-)- and (+)-strand subgenomic RNA synthesis in vitro by the viral RNA-dependent RNA polymerase expressed in Escherichia coli.A novel imidazole nucleoside containing a diaminodihydro-S-triazine as a substituent: inhibitory activity against the West Nile virus NTPase/helicase.Tropolone and its derivatives as inhibitors of the helicase activity of hepatitis C virus nucleotide triphosphatase/helicase.Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses.NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.Targeting Dengue Virus NS-3 Helicase by Ligand based Pharmacophore Modeling and Structure based Virtual Screening.Allostery in the dengue virus NS3 helicase: Insights into the NTPase cycle from molecular simulations.Insights into dengue virus genome replication
P2860
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P2860
Purification and Characterization of West Nile Virus Nucleoside Triphosphatase (NTPase)/Helicase: Evidence for Dissociation of the NTPase and Helicase Activities of the Enzyme
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Purification and Characterizat ...... icase Activities of the Enzyme
@ast
Purification and Characterizat ...... icase Activities of the Enzyme
@en
Purification and Characterizat ...... icase Activities of the Enzyme
@nl
type
label
Purification and Characterizat ...... icase Activities of the Enzyme
@ast
Purification and Characterizat ...... icase Activities of the Enzyme
@en
Purification and Characterizat ...... icase Activities of the Enzyme
@nl
prefLabel
Purification and Characterizat ...... icase Activities of the Enzyme
@ast
Purification and Characterizat ...... icase Activities of the Enzyme
@en
Purification and Characterizat ...... icase Activities of the Enzyme
@nl
P2093
P2860
P1433
P1476
Purification and characterizat ...... icase activities of the enzyme
@en
P2093
P2860
P304
P356
10.1128/JVI.75.7.3220-3229.2001
P577
2001-04-01T00:00:00Z