Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
about
RNA helicases at work: binding and rearrangingHelicase inhibitors as specifically targeted antiviral therapy for hepatitis CInvestigation of Translocation, DNA Unwinding, and Protein Displacement by NS3h, the Helicase Domain from the Hepatitis C Virus HelicaseDomain-level rocking motion within a polymerase that translocates on single-stranded nucleic acidPhosphate release contributes to the rate-limiting step for unwinding by an RNA helicase.Kinetic mechanism for DNA unwinding by multiple molecules of Dda helicase aligned on DNA.The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase.Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral targetNovel ATP-independent RNA annealing activity of the dengue virus NS3 helicaseMechanism of nucleic acid unwinding by SARS-CoV helicase.Simultaneous binding to the tracking strand, displaced strand and the duplex of a DNA fork enhances unwinding by Dda helicaseRevisiting the central dogma one molecule at a time.Mechanisms of HCV NS3 helicase monitored by optical tweezers.Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylationStructure-based simulations of the translocation mechanism of the hepatitis C virus NS3 helicase along single-stranded nucleic acid.Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structuresTranslocation of Saccharomyces cerevisiae Pif1 helicase monomers on single-stranded DNA.Superfamily 2 helicasesMelting of Duplex DNA in the Absence of ATP by the NS3 Helicase Domain through Specific Interaction with a Single-Strand/Double-Strand JunctionHepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain.Insight into helicase mechanism and function revealed through single-molecule approaches.Kinetics of DNA unwinding by the RecD2 helicase from Deinococcus radiodurans.Ensemble and single-molecule fluorescence-based assays to monitor DNA binding, translocation, and unwinding by iron-sulfur cluster containing helicases.pH-dependent conformational changes in the HCV NS3 protein modulate its ATPase and helicase activities.Single-base pair unwinding and asynchronous RNA release by the hepatitis C virus NS3 helicaseBinding by the hepatitis C virus NS3 helicase partially melts duplex DNA.Unmasking the active helicase conformation of nonstructural protein 3 from hepatitis C virus.Oligomerization of DNMT3A controls the mechanism of de novo DNA methylationNS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA.Structure and function of Pif1 helicase.
P2860
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P2860
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
description
2009 nî lūn-bûn
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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
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2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
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name
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
@ast
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
@en
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
@nl
type
label
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
@ast
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
@en
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
@nl
prefLabel
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
@ast
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
@en
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
@nl
P2093
P2860
P356
P1476
Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase
@en
P2093
Anna Marie Pyle
Rudolf K F Beran
Victor Serebrov
P2860
P304
P356
10.1074/JBC.M805460200
P407
P577
2009-01-23T00:00:00Z