Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response - sprookjes - yvandenbroek - TriplyDB

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response

http://www.wikidata.org/entity/Q27487784

about

A new insight into hepatitis C vaccine development Hepatitis C virus adaptation to T-cell immune pressure Immune responses to HCV and other hepatitis viruses Influence of HIV and HCV on T cell antigen presentation and challenges in the development of vaccines Emerging concepts in immunity to hepatitis C virus infection.T cell responses in hepatitis C virus infection: historical overview and goals for future research Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections Protective immunity against hepatitis C: many shades of gray.Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity.Structural basis for broad neutralization of hepatitis C virus quasispecies.Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation Immune control and failure in HCV infection--tipping the balance.Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes.Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection Galectin-9 and IL-21 mediate cross-regulation between Th17 and Treg cells during acute hepatitis C.Tetramer enrichment reveals the presence of phenotypically diverse hepatitis C virus-specific CD8+ T cells in chronic infection.Characterization of antigenic variants of hepatitis C virus in immune evasion.Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection.Role of host genetic factors in the outcome of hepatitis C virus infection.Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations.Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8⁺ T cells in early viral evolution.Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase.Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope.Anti-hepatitis C virus T-cell immunity in the context of multiple exposures to the virus.Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells Update on hepatitis C virus-specific immunity HLA Preferences for Conserved Epitopes: A Potential Mechanism for Hepatitis C Clearance.Constraints on viral evolution during chronic hepatitis C virus infection arising from a common-source exposure.Immunity and hepatitis C: a review.Ever closer to a prophylactic vaccine for HCV.The Associations of HLA-A*02:01 and DRB1*11:01 with Hepatitis C Virus Spontaneous Clearance Are Independent of IL28B in the Chinese Population.Therapeutic DNA vaccination using in vivo electroporation followed by standard of care therapy in patients with genotype 1 chronic hepatitis C.Between Scylla and Charybdis: the role of the human immune system in the pathogenesis of hepatitis C.HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope.Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.

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P2860

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response

http://www.wikidata.org/entity/Q27487784

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Loss of viral fitness and cros ...... stricted human immune response

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Loss of viral fitness and cros ...... stricted human immune response

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Loss of viral fitness and cros ...... stricted human immune response

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Loss of viral fitness and cros ...... stricted human immune response

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Loss of viral fitness and cros ...... stricted human immune response

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Loss of viral fitness and cros ...... stricted human immune response

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Loss of viral fitness and cros ...... stricted human immune response

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Loss of viral fitness and cros ...... stricted human immune response

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Loss of viral fitness and cros ...... stricted human immune response

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Journal of Clinical Investigation

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Loss of viral fitness and cros ...... stricted human immune response

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Christoph Neumann-Haefelin

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Dermot Kelleher

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Eva Dazert

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Hubert E Blum

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Hugo R Rosen

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Jaqueline Shaw

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John E Tavis

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Julia Kort

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Jörg Timm

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Karen Fitzmaurice

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P2860

Persistent and transient replication of full-length hepatitis C virus genomes in cell culture

Genetic Analysis of Sequences in the 3' Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication

Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

Evidence of Viral Adaptation to HLA Class I-Restricted Immune Pressure in Chronic Hepatitis C Virus Infection

Viral Sequence Evolution in Acute Hepatitis C Virus Infection

Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection

Limited T Cell Receptor Diversity of HCV-specific T Cell Responses Is Associated with CTL Escape

CD8 Epitope Escape and Reversion in Acute HCV Infection

Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man

Divergent and convergent evolution after a common-source outbreak of hepatitis C virus

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376-86

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4007388

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10.1172/JCI36587

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2

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119

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Ralf Bartenschlager

Stéphane Bressanelli

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2009-02-01T00:00:00Z

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19139562

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2631298

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