Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1
about
The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerizationSignal-dependent membrane targeting by pleckstrin homology (PH) domainsStructural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domainStructural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex.Structural basis for the specific recognition of RET by the Dok1 phosphotyrosine binding domainSignaling via Shc family adapter proteinsInteraction domains: from simple binding events to complex cellular behaviorNovel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cellsRegulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylationEDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thalianaPhosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to inDiscovery of a novel class of AKT pleckstrin homology domain inhibitors.Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activityTwo new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism.PTB or not PTB -- that is the question.Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease.Phosphotyrosine recognition domains: the typical, the atypical and the versatile.The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.Insulin signaling meets mitochondria in metabolism.Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.Structural mechanisms of the agrin-LRP4-MuSK signaling pathway in neuromuscular junction differentiation.Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments.Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways.Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells.Fluorescent indicators for imaging protein phosphorylation in single living cells.Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase.Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cellsInsulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting.The insulin receptor substrate (IRS)-1 pleckstrin homology domain functions in downstream signaling.TFIIH contains a PH domain involved in DNA nucleotide excision repair.Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states.Increased intracellular Ca2+ concentrations prevent membrane localization of PH domains through the formation of Ca2+-phosphoinositides.IRS1 and IRS2: molecular characterization, tissue expression and transcriptional regulation by insulin in yellow catfish Pelteobagrus fulvidraco.Mapping the structural topology of IRS family cascades through computational biology.Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces.Engineering the phosphoinositide-binding profile of a class I pleckstrin homology domain.Identification of a novel invasion-promoting region in Insulin Receptor Substrate 2 (IRS2).
P2860
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P2860
Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structure of the pleck ...... f insulin receptor substrate 1
@ast
Crystal structure of the pleck ...... f insulin receptor substrate 1
@en
Crystal structure of the pleck ...... f insulin receptor substrate 1
@nl
type
label
Crystal structure of the pleck ...... f insulin receptor substrate 1
@ast
Crystal structure of the pleck ...... f insulin receptor substrate 1
@en
Crystal structure of the pleck ...... f insulin receptor substrate 1
@nl
prefLabel
Crystal structure of the pleck ...... f insulin receptor substrate 1
@ast
Crystal structure of the pleck ...... f insulin receptor substrate 1
@en
Crystal structure of the pleck ...... f insulin receptor substrate 1
@nl
P2093
P2860
P356
P1476
Crystal structure of the pleck ...... f insulin receptor substrate 1
@en
P2093
E A Ottinger
S Dhe-Paganon
S E Shoelson
P2860
P304
P356
10.1073/PNAS.96.15.8378
P407
P577
1999-07-20T00:00:00Z