2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity
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Onto better TRAILs for cancer treatmentPrinciples of antibody-mediated TNF receptor activationCrystal structure of TRAIL-DR5 complex identifies a critical role of the unique frame insertion in conferring recognition specificityCrystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificityCrystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolutionStructural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5Structure of the Chlamydia trachomatis Immunodominant Antigen Pgp3Overview of protein structural and functional folds.The methionine-aromatic motif plays a unique role in stabilizing protein structure.Possible novel therapy for malignant gliomas with secretable trimeric TRAIL.TNF alpha and the TNF receptor superfamily: structure-function relationship(s).Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer.The transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity.Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity.The TRAIL to viral pathogenesis: the good, the bad and the uglyTNF superfamily protein-protein interactions: feasibility of small- molecule modulationVariants of Osteoprotegerin Lacking TRAIL Binding for Therapeutic Bone Remodeling in Osteolytic Malignancies.DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer.An optimized antibody-single-chain TRAIL fusion protein for cancer therapy.Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growthTRAIL gene therapy: from preclinical development to clinical application.TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies.TRAIL receptor signaling and therapeutic option in bone tumors: the trap of the bone microenvironment.Resistance to TRAIL and how to surmount it.Regulation of the human TRAIL gene.Role of pancreatic β-cell death and inflammation in diabetes.Interleukin-10 up-regulates tumour-necrosis-factor-alpha-related apoptosis-inducing ligand (TRAIL) gene expression in mammary epithelial cells at the involution stage.Death ligands and granulysin: mechanisms of tumor cell death induction and therapeutic opportunities.Preparation and characterization of a novel variant of human tumor necrosis factor-related apoptosis-inducing ligand from the rhesus monkey, Macaca mulatta.A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing.The extracellular matrix glycoprotein elastin microfibril interface located protein 2: a dual role in the tumor microenvironment.Cancer gene therapy using a novel secretable trimeric TRAIL.Human menstrual blood-derived mesenchymal stem cells as a cellular vehicle for malignant glioma gene therapyCrystallization and preliminary X-ray crystallographic study of the extracellular domain of the 4-1BB ligand, a member of the TNF family.Functional analysis of tumour necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL): cysteine-230 plays a critical role in the homotrimerization and biological activity of this novel tumoricidal cytokine.Hypoxic resistance to articular chondrocyte apoptosis--a possible mechanism of maintaining homeostasis of normal articular cartilage.Resistance of mitochondrial DNA-deficient cells to TRAIL: role of Bax in TRAIL-induced apoptosis.Association of human tumor necrosis factor-related apoptosis inducing ligand with membrane upon acidification.Interferon-activated neutrophils store a TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) intracellular pool that is readily mobilizable following exposure to proinflammatory mediators.Death Receptors: New Opportunities in Cancer Therapy.
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P2860
2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
2.8 A resolution crystal struc ...... h selective antitumor activity
@ast
2.8 A resolution crystal struc ...... h selective antitumor activity
@en
2.8 A resolution crystal struc ...... h selective antitumor activity
@nl
type
label
2.8 A resolution crystal struc ...... h selective antitumor activity
@ast
2.8 A resolution crystal struc ...... h selective antitumor activity
@en
2.8 A resolution crystal struc ...... h selective antitumor activity
@nl
prefLabel
2.8 A resolution crystal struc ...... h selective antitumor activity
@ast
2.8 A resolution crystal struc ...... h selective antitumor activity
@en
2.8 A resolution crystal struc ...... h selective antitumor activity
@nl
P2093
P3181
P1433
P1476
2.8 A resolution crystal struc ...... h selective antitumor activity
@en
P2093
P304
P3181
P356
10.1016/S1074-7613(00)80100-4
P407
P577
1999-08-01T00:00:00Z