Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue
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Conserved protein YecM fromEscherichia coli shows structural homology to metal-binding isomerases and oxygenasesThe identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase IZopolrestat as a human glyoxalase I inhibitor and its structural basisCharacterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterpartsGlyoxalase I of the malarial parasite Plasmodium falciparum: evidence for subunit fusionPosttranslational modification of human glyoxalase 1 indicates redox-dependent regulation(PS)2: protein structure prediction serverModulating glyoxalase I metal selectivity by deletional mutagenesis: underlying structural factors contributing to nickel activation profiles.Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxificationHsp31 of Escherichia coli K-12 is glyoxalase III.Force field independent metal parameters using a nonbonded dummy model.A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania majorNonredox nickel enzymes.Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme.Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I.Glutathione conjugates and their synthetic derivatives as inhibitors of glutathione-dependent enzymes involved in cancer and drug resistance.Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.Structural variation in bacterial glyoxalase I enzymes: investigation of the metalloenzyme glyoxalase I from Clostridium acetobutylicum.Structure of the novel monomeric glyoxalase I from Zea maysIdentification and Characterization of a Glyoxalase I Gene in a Rapeseed Cultivar with Seed ThermotoleranceMolecular enzymology of the glyoxalase system.An overview on the role of methylglyoxal and glyoxalases in plants.Methylglyoxal metabolism in trypanosomes and leishmania.Advanced glycation end products and diabetic retinopathy.Yeast glyoxalase I is a monomeric enzyme with two active sites.Novel glyoxalase-I inhibitors possessing a "zinc-binding feature" as potential anticancer agents.Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of glyoxalase I from Leishmania infantum.Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor.Investigation of metal binding and activation of Escherichia coli glyoxalase I: kinetic, thermodynamic and mutagenesis studies.Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I.Using reaction mechanism to measure enzyme similarity.Functional residues on the enzyme active site of glyoxalase I from bovine brain.A dynamic zinc redox switch.Allosteric coupling of two different functional active sites in monomeric Plasmodium falciparum glyoxalase I.A nuclear-localized rice glyoxalase I enzyme, OsGLYI-8, functions in the detoxification of methylglyoxal in the nucleus.Computational and experimental exploration of the structure-activity relationships of flavonoids as potent glyoxalase-I inhibitors.
P2860
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P2860
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Reaction mechanism of glyoxala ...... th a transition state analogue
@ast
Reaction mechanism of glyoxala ...... th a transition state analogue
@en
Reaction mechanism of glyoxala ...... th a transition state analogue
@nl
type
label
Reaction mechanism of glyoxala ...... th a transition state analogue
@ast
Reaction mechanism of glyoxala ...... th a transition state analogue
@en
Reaction mechanism of glyoxala ...... th a transition state analogue
@nl
prefLabel
Reaction mechanism of glyoxala ...... th a transition state analogue
@ast
Reaction mechanism of glyoxala ...... th a transition state analogue
@en
Reaction mechanism of glyoxala ...... th a transition state analogue
@nl
P2093
P3181
P356
P1433
P1476
Reaction mechanism of glyoxala ...... th a transition state analogue
@en
P2093
B Mannervik
D J Creighton
M J Kavarana
M Ridderström
P304
13480-13490
P3181
P356
10.1021/BI990696C
P407
P577
1999-10-01T00:00:00Z