Crystal structure of a conformation-selective casein kinase-1 inhibitor - sprookjes - yvandenbroek - TriplyDB

Crystal structure of a conformation-selective casein kinase-1 inhibitor

Crystal structure of a conformation-selective casein kinase-1 inhibitor

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The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis Recent developments of protein kinase inhibitors as potential AD therapeutics Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2 Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells Casein kinase I regulates membrane binding by ARF GAP1.Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage 2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/ε Sequential interactions with Sec23 control the direction of vesicle traffic PTEN regulates cilia through Dishevelled.Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1δ and CK1ε Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis.Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER-Golgi traffic and macroautophagy.Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.CK1epsilon is required for breast cancers dependent on beta-catenin activity.Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors.Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases.Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo Casein kinase 1 regulates connexin-43 gap junction assembly.CK1 activates minus-end-directed transport of membrane organelles along microtubules.CKI isoforms α and ε regulate Star-PAP target messages by controlling Star-PAP poly(A) polymerase activity and phosphoinositide stimulation.Circadian metabolic regulation through crosstalk between casein kinase 1δ and transcriptional coactivator PGC-1α.Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts.From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.Functional genomics identifies therapeutic targets for MYC-driven cancer.Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.Intensity statistics in the presence of translational noncrystallographic symmetry.Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.Casein kinase: the triple meaning of a misnomer.Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.Casein kinases as potential therapeutic targets.CK1δ kinase activity is modulated by protein kinase C α (PKCα)-mediated site-specific phosphorylation.Non-kinase targets of protein kinase inhibitors.Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo

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P2860

Crystal structure of a conformation-selective casein kinase-1 inhibitor

http://www.wikidata.org/entity/Q27622090

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2000 nî lūn-bûn

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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2000年の論文

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2000年論文

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2000年論文

@zh-hant

2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Crystal structure of a conformation-selective casein kinase-1 inhibitor

@ast

Crystal structure of a conformation-selective casein kinase-1 inhibitor

@en

Crystal structure of a conformation-selective casein kinase-1 inhibitor

@nl

type

label

Crystal structure of a conformation-selective casein kinase-1 inhibitor

@ast

Crystal structure of a conformation-selective casein kinase-1 inhibitor

@en

Crystal structure of a conformation-selective casein kinase-1 inhibitor

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prefLabel

Crystal structure of a conformation-selective casein kinase-1 inhibitor

@ast

Crystal structure of a conformation-selective casein kinase-1 inhibitor

@en

Crystal structure of a conformation-selective casein kinase-1 inhibitor

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

Crystal structure of a conformation-selective casein kinase-1 inhibitor

@en

P2093

A J DeMaggio

http://www.w3.org/2001/XMLSchema#string

J Kuret

http://www.w3.org/2001/XMLSchema#string

M Egli

http://www.w3.org/2001/XMLSchema#string

M F Hoekstra

http://www.w3.org/2001/XMLSchema#string

N Mashhoon

http://www.w3.org/2001/XMLSchema#string

S C Bergmeier

http://www.w3.org/2001/XMLSchema#string

P2860

Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

PROCHECK: a program to check the stereochemical quality of protein structures

Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition

Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility

The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

P304

20052-60

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scholarly article

P356

10.1074/JBC.M001713200

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P407

P433

26

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P478

275

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P50

Valentina Tereshko

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2000-06-30T00:00:00Z

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P698

10749871

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P921

crystal structure