Crystal structure of a conformation-selective casein kinase-1 inhibitor
about
The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisRecent developments of protein kinase inhibitors as potential AD therapeuticsCasein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowthPhosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cellsCasein kinase I regulates membrane binding by ARF GAP1.Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complexMicrotubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/εSequential interactions with Sec23 control the direction of vesicle trafficPTEN regulates cilia through Dishevelled.Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1δ and CK1εRegulation of Alzheimer's disease amyloid-beta formation by casein kinase IIC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis.Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER-Golgi traffic and macroautophagy.Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.CK1epsilon is required for breast cancers dependent on beta-catenin activity.Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors.Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases.Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivoCasein kinase 1 regulates connexin-43 gap junction assembly.CK1 activates minus-end-directed transport of membrane organelles along microtubules.CKI isoforms α and ε regulate Star-PAP target messages by controlling Star-PAP poly(A) polymerase activity and phosphoinositide stimulation.Circadian metabolic regulation through crosstalk between casein kinase 1δ and transcriptional coactivator PGC-1α.Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts.From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.Functional genomics identifies therapeutic targets for MYC-driven cancer.Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.Intensity statistics in the presence of translational noncrystallographic symmetry.Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrestPharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.Casein kinase: the triple meaning of a misnomer.Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.Casein kinases as potential therapeutic targets.CK1δ kinase activity is modulated by protein kinase C α (PKCα)-mediated site-specific phosphorylation.Non-kinase targets of protein kinase inhibitors.Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo
P2860
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P2860
Crystal structure of a conformation-selective casein kinase-1 inhibitor
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2000 nî lūn-bûn
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2000 թվականի հունիսին հրատարակված գիտական հոդված
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Crystal structure of a conformation-selective casein kinase-1 inhibitor
@ast
Crystal structure of a conformation-selective casein kinase-1 inhibitor
@en
Crystal structure of a conformation-selective casein kinase-1 inhibitor
@nl
type
label
Crystal structure of a conformation-selective casein kinase-1 inhibitor
@ast
Crystal structure of a conformation-selective casein kinase-1 inhibitor
@en
Crystal structure of a conformation-selective casein kinase-1 inhibitor
@nl
prefLabel
Crystal structure of a conformation-selective casein kinase-1 inhibitor
@ast
Crystal structure of a conformation-selective casein kinase-1 inhibitor
@en
Crystal structure of a conformation-selective casein kinase-1 inhibitor
@nl
P2093
P2860
P356
P1476
Crystal structure of a conformation-selective casein kinase-1 inhibitor
@en
P2093
A J DeMaggio
M F Hoekstra
N Mashhoon
S C Bergmeier
P2860
P304
P356
10.1074/JBC.M001713200
P407
P577
2000-06-30T00:00:00Z