Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator
about
Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactionsHigh-performance drug discovery: computational screening by combining docking and molecular dynamics simulationsPacking defects as selectivity switches for drug-based protein inhibitors2-Amidino analogs of glycine-amiloride conjugates: inhibitors of urokinase-type plasminogen activator.Incomplete protein packing as a selectivity filter in drug design.Development of a Mammalian suspension culture for expression of active recombinant human urokinase-type plasminogen activator.Calculation of protein-ligand binding free energy by using a polarizable potential.Molecular dynamics simulations of Factor Xa: insight into conformational transition of its binding subsites.Application of long-acting VLHL PAI-1 during sutureless partial nephrectomy in mice reduces bleeding.Thrombin-thrombomodulin inhibits prourokinase-mediated pleural mesothelial cell-dependent fibrinolysis.Assessing the similarity of ligand binding conformations with the Contact Mode Score.Quantitative Correlation of Conformational Binding Enthalpy with Substrate Specificity of Serine Proteases.Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.Comparative binding energy analysis for binding affinity and target selectivity prediction.A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.Prediction of trypsin/molecular fragment binding affinities by free energy decomposition and empirical scores.Protein promiscuity: drug resistance and native functions--HIV-1 case.Epistructural Selectivity Filters for Molecular Targeted Therapy
P2860
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P2860
Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator
description
2000 nî lūn-bûn
@nan
2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Structural basis for selectivi ...... ase-type plasminogen activator
@ast
Structural basis for selectivi ...... ase-type plasminogen activator
@en
Structural basis for selectivi ...... ase-type plasminogen activator
@nl
type
label
Structural basis for selectivi ...... ase-type plasminogen activator
@ast
Structural basis for selectivi ...... ase-type plasminogen activator
@en
Structural basis for selectivi ...... ase-type plasminogen activator
@nl
prefLabel
Structural basis for selectivi ...... ase-type plasminogen activator
@ast
Structural basis for selectivi ...... ase-type plasminogen activator
@en
Structural basis for selectivi ...... ase-type plasminogen activator
@nl
P2093
P1476
Structural basis for selectivi ...... ase-type plasminogen activator
@en
P2093
A Martelli
P A Sprengeler
P304
P356
10.1016/S1074-5521(00)00104-6
P577
2000-04-01T00:00:00Z