The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance
about
Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistanceSelf-resistance in Streptomyces, with Special Reference to β-Lactam AntibioticsThe Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureusStructure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureusThe structural modifications induced by the M339F substitution in PBP2x from Streptococcus pneumoniae further decreases the susceptibility to beta-lactams of resistant strainsA PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibioticsCrystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for Its High Antimicrobial ActivityCrystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniaeFunctional and Structural Characterization of Four Glutaminases from Escherichia coli and Bacillus subtilis †Unusual Conformation of the SxN Motif in the Crystal Structure of Penicillin-Binding Protein A from Mycobacterium tuberculosisCrystal Structures of Covalent Complexes of β-Lactam Antibiotics with Escherichia coli Penicillin-Binding Protein 5: Toward an Understanding of Antibiotic SpecificityCrystal Structures of Penicillin-Binding Protein 3 from Pseudomonas aeruginosa: Comparison of Native and Antibiotic-Bound FormsX-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureusThe Role of the β5–α11 Loop in the Active-Site Dynamics of Acylated Penicillin-Binding Protein A from Mycobacterium tuberculosisCrystal Structures of Bifunctional Penicillin-Binding Protein 4 from Listeria monocytogenesHow allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological functionStructural Analysis of Staphylococcus aureus Serine/Threonine Kinase PknBStructural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosisPenicillin-binding proteins and beta-lactam resistanceComparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strainMolecular dynamics simulation of the complex PBP-2x with drug cefuroxime to explore the drug resistance mechanism of Streptococcus suis R61The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective.Insight into the Diversity of Penicillin-Binding Protein 2x Alleles and Mutations in Viridans Streptococci.Evidence of an intramolecular interaction between the two domains of the BlaR1 penicillin receptor during the signal transduction.The highly conserved serine threonine kinase StkP of Streptococcus pneumoniae contributes to penicillin susceptibility independently from genes encoding penicillin-binding proteins.Septal and lateral wall localization of PBP5, the major D,D-carboxypeptidase of Escherichia coli, requires substrate recognition and membrane attachment.Amino acid mutations essential to production of an altered PBP 2X conferring high-level beta-lactam resistance in a clinical isolate of Streptococcus pneumoniae.Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations.Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agent.Recognition of peptidoglycan and β-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae.FemABX peptidyl transferases: a link between branched-chain cell wall peptide formation and beta-lactam resistance in gram-positive cocci.Mutational analysis of class A and class B penicillin-binding proteins in Streptococcus gordonii.The ybxI gene of Bacillus subtilis 168 encodes a class D beta-lactamase of low activity.Profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39A Serine-Threonine Kinase (StkP) Regulates Expression of the Pneumococcal Pilus and Modulates Bacterial Adherence to Human Epithelial and Endothelial Cells In Vitro.Strain features and distributions in pneumococci from children with invasive disease before and after 13-valent conjugate vaccine implementation in the USA.A highly conserved interaction involving the middle residue of the SXN active-site motif is crucial for function of class B penicillin-binding proteins: mutational and computational analysis of PBP 2 from N. gonorrhoeaeMessenger functions of the bacterial cell wall-derived muropeptides.Impact of specific pbp5 mutations on expression of beta-lactam resistance in Enterococcus faecium.
P2860
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P2860
The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance
description
2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
@wuu
name
The crystal structure of the p ...... implication in drug resistance
@ast
The crystal structure of the p ...... implication in drug resistance
@en
The crystal structure of the p ...... implication in drug resistance
@nl
type
label
The crystal structure of the p ...... implication in drug resistance
@ast
The crystal structure of the p ...... implication in drug resistance
@en
The crystal structure of the p ...... implication in drug resistance
@nl
prefLabel
The crystal structure of the p ...... implication in drug resistance
@ast
The crystal structure of the p ...... implication in drug resistance
@en
The crystal structure of the p ...... implication in drug resistance
@nl
P2093
P3181
P356
P1476
The crystal structure of the p ...... implication in drug resistance
@en
P2093
P304
P3181
P356
10.1006/JMBI.2000.3740
P407
P577
2000-06-02T00:00:00Z