Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
about
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinStepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsComputational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β -SecretaseMechanism of NS2B-Mediated Activation of NS3pro in Dengue Virus: Molecular Dynamics Simulations and BioassaysCrystal structure of type II peptide deformylase from Staphylococcus aureusAtomic resolution analysis of the catalytic site of an aspartic proteinase and an unexpected mode of binding by short peptidesPotent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluationCrystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid Protein ProductionA therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivoStructure-Based Design of Highly Selective β-Secretase Inhibitors: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Crystal StructureFlexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulationsCamel and bovine chymosin: the relationship between their structures and cheese-making propertiesVirtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitorsMapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and XaperonesTargeting mRNA for Alzheimer's and related dementias.Development and Structural Modification of BACE1 InhibitorsTrafficking and proteolytic processing of APPBACE1 expression and activity: relevance in Alzheimer's diseaseSpotlight on BACE: the secretases as targets for treatment in Alzheimer diseaseAnalysis of crystal structures of aspartic proteinases: on the role of amino acid residues adjacent to the catalytic site of pepsin-like enzymesConformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation EquilibriaTargeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesisTake five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.In silico study of peptide inhibitors against BACE 1.Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy.Selective amyloid-beta lowering agents.Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases.Investigation of protein refolding using a fractional factorial screen: a study of reagent effects and interactionsConstruction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to beta-secretase.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Enhanced red-emitting railroad worm luciferase for bioassays and bioimagingPredicting memapsin 2 (β-secretase) hydrolytic activity.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Beta-secretase: structure, function, and evolution.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseEnzymic properties of recombinant BACE2.
P2860
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P2860
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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name
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
@ast
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
@en
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
@nl
type
label
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
@ast
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
@en
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
@nl
prefLabel
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
@ast
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
@en
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
@nl
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P3181
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P1476
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
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P2093
P3181
P356
10.1126/SCIENCE.290.5489.150
P407
P577
2000-10-06T00:00:00Z