The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity
about
Multidrug resistance in bacteriaThyroxine-thyroid hormone receptor interactionsX-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genomeStructure of a cation-bound multidrug and toxic compound extrusion transporterEndogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C diseaseBile salts of vertebrates: structural variation and possible evolutionary significanceNeurosteroid regulation of central nervous system developmentStructure of P-glycoprotein reveals a molecular basis for poly-specific drug bindingPregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C diseaseAlternatively spliced isoforms of the human constitutive androstane receptorThe evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammalsEvolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.Biology of PXR: role in drug-hormone interactionsRegulation of the cytosolic sulfotransferases by nuclear receptorsModulation of xenobiotic receptors by steroidsTargeting xenobiotic receptors PXR and CAR in human diseasesStructural considerations of vitamin D signalingCrystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonismX-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switchThe three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligandsStructural plasticity in the oestrogen receptor ligand-binding domainA Single Acidic Residue Can Guide Binding Site Selection but Does Not Govern QacR Cationic-Drug AffinityActivation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRαDivergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone ReceptorsX-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding InterfaceA brief history of the discovery of PXR and CAR as xenobiotic receptorsPregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator InteractionsActivation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional stateIdentification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesX-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulationChallenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXRA PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrileStructural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptorIn silico prediction of inhibition of promiscuous breast cancer resistance protein (BCRP/ABCG2)Alterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactionsPregnane X receptor and natural products: beyond drug-drug interactionsEvolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts
P2860
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P2860
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The human nuclear xenobiotic r ...... inants of directed promiscuity
@ast
The human nuclear xenobiotic r ...... inants of directed promiscuity
@en
The human nuclear xenobiotic r ...... inants of directed promiscuity
@nl
type
label
The human nuclear xenobiotic r ...... inants of directed promiscuity
@ast
The human nuclear xenobiotic r ...... inants of directed promiscuity
@en
The human nuclear xenobiotic r ...... inants of directed promiscuity
@nl
prefLabel
The human nuclear xenobiotic r ...... inants of directed promiscuity
@ast
The human nuclear xenobiotic r ...... inants of directed promiscuity
@en
The human nuclear xenobiotic r ...... inants of directed promiscuity
@nl
P2093
P3181
P356
P1433
P1476
The human nuclear xenobiotic r ...... inants of directed promiscuity
@en
P2093
G B Wisely
J L Collins
M H Lambert
M R Redinbo
R E Watkins
S A Kliewer
S P Williams
T M Willson
P304
P3181
P356
10.1126/SCIENCE.1060762
P407
P577
2001-06-22T00:00:00Z