Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I
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Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesisMolecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAcalpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta 4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine. Crystal structure of beta 4Gal-T1 x LA complex with UDP-GlcStructure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminusStructure-based design of beta 1,4-galactosyltransferase I (beta 4Gal-T1) with equally efficient N-acetylgalactosaminyltransferase activity: point mutation broadens beta 4Gal-T1 donor specificityCrystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUAStructural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferaseDeoxygenated Disaccharide Analogs as Specific Inhibitors of 1-4-Galactosyltransferase 1 and Selectin-mediated Tumor MetastasisMolecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferaseCrystal Structure of the Catalytic Domain of Drosophila β1,4-Galactosyltransferase-7Binding of N-Acetylglucosamine (GlcNAc) 1-6-branched Oligosaccharide Acceptors to 4-Galactosyltransferase I Reveals a New Ligand Binding ModeMechanistic Insights into the Retaining Glucosyl-3-phosphoglycerate Synthase from MycobacteriaInvestigations on β1,4-galactosyltransferase I using 6-sulfo-GlcNAc as an acceptor sugar substrateEffects of glucose availability on expression of the key genes involved in synthesis of milk fat, lactose and glucose metabolism in bovine mammary epithelial cellsApplications of site-specific labeling to study HAMLET, a tumoricidal complex of α-lactalbumin and oleic acid.The evolution of milk secretion and its ancient origins.4-O-Acetyl-sialic acid (Neu4,5Ac2) in acidic milk oligosaccharides of the platypus (Ornithorhynchus anatinus) and its evolutionary significance.The N-acetyl-binding pocket of N-acetylglucosaminyltransferases also accommodates a sugar analog with a chemical handle at C2.Role of a single amino acid in the evolution of glycans of invertebrates and vertebratesSubstrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2.Structure and function of beta -1,4-galactosyltransferaseLarge-scale modulation of thermodynamic protein folding barriers linked to electrostaticsX-ray crystal structure of leukocyte type core 2 beta1,6-N-acetylglucosaminyltransferase. Evidence for a convergence of metal ion-independent glycosyltransferase mechanism.Proteomic analysis to unravel the effect of heat stress on gene expression and milk synthesis in bovine mammary epithelial cells.Bacterial Glycosyltransferases: Challenges and Opportunities of a Highly Diverse Enzyme Class Toward Tailoring Natural Products.Glycosyltransferase engineering for carbohydrate synthesis.Metabolic Transition of Milk Lactose Synthesis and Up-regulation by AKT1 in Sows from Late Pregnancy to Lactation.Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway.Landscape of protein-small ligand binding modes.Glycosyltransferase mechanisms: impact of a 5-fluoro substituent in acceptor and donor substrates on catalysis.Modulating functional loop movements: the role of highly conserved residues in the correlated loop motions.Bos indicus introgression into (peri-)alpine cattle breeds - evidence from the analysis of bovine whey protein variants.Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans.Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.Evaluation of critical structural elements of UDP-sugar substrates and certain cysteine residues of a vertebrate hyaluronan synthase.Proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I is essential for viability in Drosophila melanogaster.Comparison of the closed conformation of the beta 1,4-galactosyltransferase-1 (beta 4Gal-T1) in the presence and absence of alpha-lactalbumin (LA).DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content.Expression system for structural and functional studies of human glycosylation enzymes.The effect of long term under- and over-feeding on the expression of genes related to glucose metabolism in mammary tissue of sheep.
P2860
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P2860
Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structure of lactose s ...... eta1,4-galactosyltransferase-I
@ast
Crystal structure of lactose s ...... eta1,4-galactosyltransferase-I
@en
Crystal structure of lactose s ...... eta1,4-galactosyltransferase-I
@nl
type
label
Crystal structure of lactose s ...... eta1,4-galactosyltransferase-I
@ast
Crystal structure of lactose s ...... eta1,4-galactosyltransferase-I
@en
Crystal structure of lactose s ...... eta1,4-galactosyltransferase-I
@nl
prefLabel
Crystal structure of lactose s ...... eta1,4-galactosyltransferase-I
@ast
Crystal structure of lactose s ...... eta1,4-galactosyltransferase-I
@en
Crystal structure of lactose s ...... eta1,4-galactosyltransferase-I
@nl
P921
P3181
P356
P1476
Crystal structure of lactose s ...... eta1,4-galactosyltransferase-I
@en
P2093
B Ramakrishnan
P304
P3181
P356
10.1006/JMBI.2001.4757
P407
P577
2001-06-29T00:00:00Z