Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
about
Borrelia burgdorferi changes its surface antigenic expression in response to host immune responsesRapid model building of alpha-helices in electron-density mapsCrowded, cell-like environment induces shape changes in aspherical proteinMini-review: Strategies for Variation and Evolution of Bacterial Antigensvls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework HeterogeneityMicrobial antigenic variation mediated by homologous DNA recombinationWhat macromolecular crowding can do to a proteinUrea denatured state ensembles contain extensive secondary structure that is increased in hydrophobic proteinsContribution of hydrogen bonds to protein stabilityDecision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizardDynameomics: data-driven methods and models for utilizing large-scale protein structure repositories for improving fragment-based loop prediction.Use of Peptide library screening to detect a previously unknown linear diagnostic epitope: proof of principle by use of lyme disease sera.Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase.Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi.Borrelia burgdorferi adhesins identified using in vivo phage display.Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection.Rapid model building of beta-sheets in electron-density mapsRapid chain tracing of polypeptide backbones in electron-density mapsEpitope mapping of antibodies to VlsE protein of Borrelia burgdorferi in post-Lyme disease syndromeAntigenic composition of Borrelia burgdorferi during infection of SCID mice.Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva.Genetic variation at the vlsE locus of Borrelia burgdorferi within ticks and mice over the course of a single transmission cycle.The absence of linear plasmid 25 or 28-1 of Borrelia burgdorferi dramatically alters the kinetics of experimental infection via distinct mechanisms.Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivityOuter membrane proteins of pathogenic spirochetes.'Nothing is permanent but change'- antigenic variation in persistent bacterial pathogensThe burgeoning molecular genetics of the Lyme disease spirochaete.Dominant epitopes of the C6 diagnostic peptide of Borrelia burgdorferi are largely inaccessible to antibody on the parent VlsE moleculeEpitope-Specific Evolution of Human B Cell Responses to Borrelia burgdorferi VlsE Protein from Early to Late Stages of Lyme Disease.Cross-species surface display of functional spirochetal lipoproteins by recombinant Borrelia burgdorferi.Antigenic Variation in Bacterial Pathogens.Functional Equivalence of OspA and OspB, but Not OspC, in Tick Colonization by Borrelia burgdorferiEvaluation of RevA, a fibronectin-binding protein of Borrelia burgdorferi, as a potential vaccine candidate for lyme disease.Evaluation of the recombinant VlsE-based liaison chemiluminescence immunoassay for detection of Borrelia burgdorferi and diagnosis of Lyme disease.Lipoprotein succession in Borrelia burgdorferi: similar but distinct roles for OspC and VlsE at different stages of mammalian infectionOspC-independent infection and dissemination by host-adapted Borrelia burgdorferiFolding, stability and shape of proteins in crowded environments: experimental and computational approachesExperimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycleEffects of vlsE complementation on the infectivity of Borrelia burgdorferi lacking the linear plasmid lp28-1.Emerging roles for the BAI1 protein family in the regulation of phagocytosis, synaptogenesis, neurovasculature, and tumor development.
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P2860
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
description
2002 nî lūn-bûn
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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2002 թվականի հունիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
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2002年論文
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2002年論文
@zh-tw
2002年论文
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name
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
@ast
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
@en
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
@nl
type
label
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
@ast
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
@en
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
@nl
prefLabel
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
@ast
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
@en
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
@nl
P2093
P2860
P921
P356
P1476
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi
@en
P2093
Christoph Eicken
James C Sacchettini
John M Hardham
Matthew B Lawrenz
Thomas Klabunde
Vivek Sharma
P2860
P304
P356
10.1074/JBC.M201547200
P407
P577
2002-06-14T00:00:00Z