Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
about
A model of the ternary complex of interleukin-10 with its soluble receptors.The cytomegalovirus homolog of interleukin-10 requires phosphatidylinositol 3-kinase activity for inhibition of cytokine synthesis in monocytesHerpesvirus exploitation of host immune inhibitory pathwaysCrystal structure of interleukin-19 defines a new subfamily of helical cytokinesStructure and Mechanism of Receptor Sharing by the IL-10R2 Common ChainCrystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1Exploiting viral natural history for vaccine developmentStructural mapping of post-translational modifications in human interleukin-24: role of N-linked glycosylation and disulfide bonds in secretion and activityHerpesviral capture of immunomodulatory host genes.Virus-encoded homologs of cellular interleukin-10 and their control of host immune function.HCMV IL-10 suppresses cytokine expression in monocytes through inhibition of nuclear factor-kappaB.Design and analysis of rhesus cytomegalovirus IL-10 mutants as a model for novel vaccines against human cytomegalovirusEffect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.Epstein-Barr virus IL-10 gene expression by a recombinant murine gammaherpesvirus in vivo enhances acute pathogenicity but does not affect latency or reactivation.Structural analysis of cytokines comprising the IL-10 familyAttenuation of innate immunity by cytomegalovirus IL-10 establishes a long-term deficit of adaptive antiviral immunityTargeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potencySecretory expression of biologically active human Herpes virus interleukin-10 analogues in Escherichia coli via a modified Sec-dependent transporter constructPurification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex.Mechanistic diversity of cytokine receptor signaling across cell membranes.The molecular basis of IL-10 function: from receptor structure to the onset of signaling.Viral strategies for evading antiviral cellular immune responses of the host.Human cytomegalovirus encoded homologs of cytokines, chemokines and their receptors: roles in immunomodulation.Viable Borrelia burgdorferi enhances interleukin-10 production and suppresses activation of murine macrophages.Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection.Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitroHuman cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic ProteinHuman Cytomegalovirus-Encoded Human Interleukin-10 (IL-10) Homolog Amplifies Its Immunomodulatory Potential by Upregulating Human IL-10 in MonocytesVaccination against a virus-encoded cytokine significantly restricts viral challengeThe tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus.Human cytomegalovirus interleukin-10 enhances matrigel invasion of MDA-MB-231 breast cancer cells.Human cytomegalovirus latent infection and associated viral gene expression.Human cytomegalovirus manipulation of latently infected cells.Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus.Stimulation of B lymphocytes by cmvIL-10 but not LAcmvIL-10Viral manipulation of the host immune response.Diverse mechanisms evolved by DNA viruses to inhibit early host defenses.Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures.
P2860
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P2860
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1
@nl
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
@ast
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
@en
type
label
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1
@nl
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
@ast
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
@en
prefLabel
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1
@nl
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
@ast
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
@en
P2093
P2860
P356
P1476
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
@en
P2093
Brandi C Jones
Jennifer Cook
Kristopher Josephson
Mark R Walter
Naomi J Logsdon
Peter A Barry
P2860
P304
P356
10.1073/PNAS.152147499
P407
P577
2002-07-01T00:00:00Z