Crystal structure of aurora-2, an oncogenic serine/threonine kinase
about
Structural evolution of the protein kinase-like superfamilyModulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2Centrosome cycle studies reveal promising candidates for anti-cancer drug designEvolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugsA Cell Biologist's Field Guide to Aurora Kinase InhibitorsCrystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitorsCrystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125Crystal Structure of Human Aurora B in Complex with INCENP and VX-680Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubulesMolecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-CThe cellular geography of aurora kinasesRecombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions.Dictyostelium Aurora kinase has properties of both Aurora A and Aurora B kinases.Benzo[e]pyridoindoles, novel inhibitors of the aurora kinases.In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitorsGlobal consequences of activation loop phosphorylation on protein kinase A.SERS and MD simulation studies of a kinase inhibitor demonstrate the emergence of a potential drug discovery toolVX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo.Histone modification enzymes: novel targets for cancer drugs.INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stabilityIdentification of transcriptional and phosphatase regulators as interaction partners of human ADA3, a component of histone acetyltransferase complexes.Aurora-A kinase-inactive mutants disrupt the interaction with Ajuba and cause defects in mitotic spindle formation and G2/M phase arrest in HeLa cells.Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cellsStructure and function of Polo-like kinases.Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosisAurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases.Aurora A and B kinases as targets for cancer: will they be selective for tumors?Targeting Aurora kinases in ovarian cancer.Reconstitution of modular PDK1 functions on trans-splicing of the regulatory PH and catalytic kinase domainsConsortium analysis of 7 candidate SNPs for ovarian cancer.Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.Alisertib induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt/mTOR- and p38 MAPK-mediated pathways in human glioblastoma cellsOn the molecular mechanisms of mitotic kinase activation.Macromolecular structures: Quality assessment and biological interpretation.A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition.Structural studies of B-type Aurora kinase inhibitors using computational methods.Switching Aurora-A kinase on and off at an allosteric site.
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P2860
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
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2002 nî lūn-bûn
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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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name
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
@ast
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
@en
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
@nl
type
label
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
@ast
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
@en
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
@nl
prefLabel
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
@ast
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
@en
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
@nl
P2093
P2860
P3181
P356
P1476
Crystal structure of aurora-2, an oncogenic serine/threonine kinase
@en
P2093
Douglas A Austen
Graham M T Cheetham
Joyce T Coll
Judith A Lippke
Lora Swenson
Peter Weber
Ronald M A Knegtel
Suzanne B Renwick
P2860
P304
P3181
P356
10.1074/JBC.C200426200
P407
P577
2002-11-08T00:00:00Z