The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis
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Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthaseStructural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoformsStructural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithinesStructural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthaseHeme-Coordinating Inhibitors of Neuronal Nitric Oxide Synthase. Iron−Thioether Coordination Is Stabilized by Hydrophobic Contacts without Increased Inhibitor PotencyMinimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase InhibitorsCrystal Structures of Constitutive Nitric Oxide Synthases in Complex with De Novo Designed Inhibitors †Single Crystal Structural and Absorption Spectral Characterizations of Nitric Oxide Synthase Complexed with N ω -Hydroxy- l -arginine and Diatomic Ligands ,Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal ModelStructure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthasePeripheral but crucial: A hydrophobic pocket (Tyr706, Leu337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthasePotent, Highly Selective, and Orally Bioavailable Gem -Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide SynthaseExploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine DerivativesTemperature-Dependent Spin Crossover in Neuronal Nitric Oxide Synthase Bound with the Heme-Coordinating Thioether InhibitorsStructure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide SynthaseMethylated N ω -Hydroxy- l -arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed ReactionIntramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthaseIn search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structuresStructural and biological studies on bacterial nitric oxide synthase inhibitorsSelective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics SimulationsPotent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of MelanomaSimplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase InhibitionThe Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide SynthasesElectrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide SynthaseCorrelating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic TrapIntraprotein electron transfer in inducible nitric oxide synthase holoenzymeRegulation of interdomain electron transfer in the NOS output state for NO productionPulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase.Computational study of the human dystrophin repeats: interaction properties and molecular dynamics.Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.Pulsed electron paramagnetic resonance study of domain docking in neuronal nitric oxide synthase: the calmodulin and output state perspective.Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions.Nitric oxide synthases activation and inhibition by metallacarborane-cluster-based isoform-specific affectors.Regulatory role of Glu546 in flavin mononucleotide-heme electron transfer in human inducible nitric oxide synthase.The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies.Pulsed ENDOR determination of relative orientation of g-frame and molecular frame of imidazole-coordinated heme center of iNOSMechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid.Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.Pulsed ENDOR determination of the arginine location in the ferrous-NO form of neuronal NOS.Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.
P2860
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P2860
The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The novel binding mode of N-al ...... insights into NO biosynthesis
@ast
The novel binding mode of N-al ...... insights into NO biosynthesis
@en
The novel binding mode of N-al ...... insights into NO biosynthesis
@nl
type
label
The novel binding mode of N-al ...... insights into NO biosynthesis
@ast
The novel binding mode of N-al ...... insights into NO biosynthesis
@en
The novel binding mode of N-al ...... insights into NO biosynthesis
@nl
prefLabel
The novel binding mode of N-al ...... insights into NO biosynthesis
@ast
The novel binding mode of N-al ...... insights into NO biosynthesis
@en
The novel binding mode of N-al ...... insights into NO biosynthesis
@nl
P2093
P3181
P356
P1433
P1476
The novel binding mode of N-al ...... insights into NO biosynthesis
@en
P2093
Edward Zhong Wen
Huiying Li
Joumana Jamal
Mack Flinspach
Peng George Wang
Thomas L Poulos
Tingwei Cai
Weiping Yang
P304
13868-13875
P3181
P356
10.1021/BI020417C
P407
P577
2002-11-01T00:00:00Z