A structural basis for immunodominant human T cell receptor recognition
about
αβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapyForward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound PeptidesCrystal Structure of Mycoplasma arthritidis Mitogen Complexed with HLA-DR1 Reveals a Novel Superantigen Fold and a Dimerized Superantigen-MHC ComplexA T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I moleculeStructural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptorCrossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC MoleculesGerm Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell ReceptorIdentification and structural definition of H5-specific CTL epitopes restricted by HLA-A*0201 derived from the H5N1 subtype of influenza A virusesAn Alternative Conformation of the T-Cell Receptor α Constant RegionNovel Immunodominant Peptide Presentation Strategy: a Featured HLA-A*2402-Restricted Cytotoxic T-Lymphocyte Epitope Stabilized by Intrachain Hydrogen Bonds from Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid ProteinGenetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus InfectionStructure of a TCR with high affinity for self-antigen reveals basis for escape from negative selectionStructural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responsesMinimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimersStructural features underlying T-cell receptor sensitivity to concealed MHC class I micropolymorphismsV 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigenT Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational RearrangementsIncreased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking modeStructure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infectionProline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptidesT cell receptor reversed polarity recognition of a self-antigen major histocompatibility complexLack of heterologous cross-reactivity towards HLA-A*02:01 restricted viral epitopes is underpinned by distinct αβT cell receptor signaturesEcological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populationsImmunity to seasonal and pandemic influenza A virusesConserved epitopes dominate cross-CD8+ T-cell responses against influenza A H1N1 virus among Asian populations.DynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles.How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoireImmunization of volunteers with Salmonella enterica serovar Typhi strain Ty21a elicits the oligoclonal expansion of CD8+ T cells with predominant Vbeta repertoires.Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral AntigensUnderstanding TR binding to pMHC complexes: how does a TR scan many pMHC complexes yet preferentially bind to one.Functional constraints of influenza A virus epitopes limit escape from cytotoxic T lymphocytesStructure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II moleculePredicting peptide binding affinities to MHC molecules using a modified semi-empirical scoring function.TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires.POPISK: T-cell reactivity prediction using support vector machines and string kernels.Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides.T Cell receptor clonotype influences epitope hierarchy in the CD8+ T cell response to respiratory syncytial virus infection.A highly restricted T-cell receptor dominates the CD8+ T-cell response to parvovirus B19 infection in HLA-A*2402-positive individuals.Vgamma2Vdelta2 T Cell Receptor recognition of prenyl pyrophosphates is dependent on all CDRsDisparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.
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P2860
A structural basis for immunodominant human T cell receptor recognition
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
A structural basis for immunodominant human T cell receptor recognition
@ast
A structural basis for immunodominant human T cell receptor recognition
@en
A structural basis for immunodominant human T cell receptor recognition
@nl
type
label
A structural basis for immunodominant human T cell receptor recognition
@ast
A structural basis for immunodominant human T cell receptor recognition
@en
A structural basis for immunodominant human T cell receptor recognition
@nl
prefLabel
A structural basis for immunodominant human T cell receptor recognition
@ast
A structural basis for immunodominant human T cell receptor recognition
@en
A structural basis for immunodominant human T cell receptor recognition
@nl
P2093
P2860
P3181
P356
P1433
P1476
A structural basis for immunodominant human T cell receptor recognition
@en
P2093
Andrew J McMichael
Guillaume B E Stewart-Jones
John I Bell
P2860
P304
P3181
P356
10.1038/NI942
P407
P577
2003-06-08T00:00:00Z