Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism
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Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatusStructural basis for Rab GTPase activation by VPS9 domain exchange factorsSorting nexin 10 induces giant vacuoles in mammalian cellsThe Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN)Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factorsA COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factorDynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the GolgiHijacking components of the cellular secretory pathway for replication of poliovirus RNARegulation of small GTPases by GEFs, GAPs, and GDIsRegulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activationRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseIntegrity of the early secretory pathway promotes, but is not required for, severe acute respiratory syndrome coronavirus RNA synthesis and virus-induced remodeling of endoplasmic reticulum membranes.Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors3D structure of a binary ROP-PRONE complex: the final intermediate for a complete set of molecular snapshots of the RopGEF reactionGDP-bound and Nucleotide-free Intermediates of the Guanine Nucleotide Exchange in the Rab5{middle dot}Vps9 SystemApproach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchangeDirect metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reactionRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p.Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesStructural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factorReverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulenceHepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cellsDecoupling polarization of the Golgi apparatus and GM1 in the plasma membraneAssembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartmentDesign of multi-specificity in protein interfacesThe distribution of ligand-binding pockets around protein-protein interfaces suggests a general mechanism for pocket formation.Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation.Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.Insight into the role of dynamics in the conformational switch of the small GTP-binding protein Arf1The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation.Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy.ER-resident proteins PDR2 and LPR1 mediate the developmental response of root meristems to phosphate availabilityA critical role of a cellular membrane traffic protein in poliovirus RNA replicationAnalysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs.A computational study of a recreated G protein-GEF reaction intermediate competent for nucleotide exchange: fate of the Mg ionSelective protection of an ARF1-GTP signaling axis by a bacterial scaffold induces bidirectional trafficking arrest.Novel effects of Brefeldin A (BFA) in signaling through the insulin receptor (IR) pathway and regulating FoxO1-mediated transcription.A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.
P2860
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P2860
Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Crystal structure of ARF1*Sec7 ...... nucleotide exchange mechanism
@ast
Crystal structure of ARF1*Sec7 ...... nucleotide exchange mechanism
@en
Crystal structure of ARF1*Sec7 ...... nucleotide exchange mechanism
@nl
type
label
Crystal structure of ARF1*Sec7 ...... nucleotide exchange mechanism
@ast
Crystal structure of ARF1*Sec7 ...... nucleotide exchange mechanism
@en
Crystal structure of ARF1*Sec7 ...... nucleotide exchange mechanism
@nl
prefLabel
Crystal structure of ARF1*Sec7 ...... nucleotide exchange mechanism
@ast
Crystal structure of ARF1*Sec7 ...... nucleotide exchange mechanism
@en
Crystal structure of ARF1*Sec7 ...... nucleotide exchange mechanism
@nl
P2093
P3181
P1433
P1476
Crystal structure of ARF1*Sec7 ...... nucleotide exchange mechanism
@en
P2093
Elena Mossessova
Jonathan Goldberg
Richard A Corpina
P304
P3181
P356
10.1016/S1097-2765(03)00475-1
P577
2003-12-01T00:00:00Z