Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis
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Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitorsChemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosisNatural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugsToward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †Iodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis InhibitorsToward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural AnalysisA Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and CytotoxicityChemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasmaTrapping of palindromic ligands within native transthyretin prevents amyloid formationPotent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte ProteotoxicityAromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent ConjugateTafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascadeStructural evidence for asymmetric ligand binding to transthyretinModulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanismsThe flavonoid luteolin, but not luteolin-7-O-glucoside, prevents a transthyretin mediated toxic responseTetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin TetramerRetrospective Mapping of SAR Data for TTR Protein in Chemico-Biological Space Using Ligand Efficiency Indices as a Guide to Drug Discovery Strategies.Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methodsDesigned Trpzip-3 β-Hairpin Inhibits Amyloid Formation in Two Different Amyloid SystemsSignificance of the amyloidogenic transthyretin Val 122 Ile allele in African Americans in the Arteriosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies.Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation.Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosisEngineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease.Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidosesStructure-activity relationships of organofluorine inhibitors of β-amyloid self-assembly.A stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate.Novel drugs targeting transthyretin amyloidosis.Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated proteinA competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis.The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugationAmyloidogenic and non-amyloidogenic transthyretin variants interact differently with human cardiomyocytes: insights into early events of non-fibrillar tissue damage.Cooperative stabilization of transthyretin by clusterin and diflunisal.Modulating inhibitors of transthyretin fibrillogenesis via sulfation: polychlorinated biphenyl sulfates as models.Bifunctional crosslinking ligands for transthyretinIdentification of Transthyretin Fibril Formation Inhibitors Using Structure-Based Virtual Screening.Statistical discovery of site inter-dependencies in sub-molecular hierarchical protein structuringRepositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.Transthyretin: the servant of many masters.
P2860
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P2860
Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Diflunisal analogues stabilize ...... inhibition of amyloidogenesis
@ast
Diflunisal analogues stabilize ...... inhibition of amyloidogenesis
@en
Diflunisal analogues stabilize ...... inhibition of amyloidogenesis
@nl
type
label
Diflunisal analogues stabilize ...... inhibition of amyloidogenesis
@ast
Diflunisal analogues stabilize ...... inhibition of amyloidogenesis
@en
Diflunisal analogues stabilize ...... inhibition of amyloidogenesis
@nl
prefLabel
Diflunisal analogues stabilize ...... inhibition of amyloidogenesis
@ast
Diflunisal analogues stabilize ...... inhibition of amyloidogenesis
@en
Diflunisal analogues stabilize ...... inhibition of amyloidogenesis
@nl
P2093
P3181
P356
P1476
Diflunisal analogues stabilize ...... inhibition of amyloidogenesis
@en
P2093
James C Sacchettini
Sara L Adamski-Werner
Satheesh K Palaninathan
P304
P3181
P356
10.1021/JM030347N
P407
P577
2004-01-15T00:00:00Z