ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis - sprookjes - yvandenbroek - TriplyDB

ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis

ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis

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A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme Coupling between catalytic site and collective dynamics: a requirement for mechanochemical activity of enzymes The SARS coronavirus S glycoprotein receptor binding domain: fine mapping and functional characterization A crucial role in fertility for the oyster angiotensin-converting enzyme orthologue CgACE Trapping conformational states along ligand-binding dynamics of peptide deformylase: the impact of induced fit on enzyme catalysis Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase Structural Analysis of Major Species Barriers between Humans and Palm Civets for Severe Acute Respiratory Syndrome Coronavirus Infections Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor The Exquisite Structure and Reaction Mechanism of Bacterial Pz-peptidase A toward Collagenous Peptides: X-RAY CRYSTALLOGRAPHIC STRUCTURE ANALYSIS OF PZ-PEPTIDASE A REVEALS DIFFERENCES FROM MAMMALIAN THIMET OLIGOPEPTIDASE Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1 Structural and Functional Analyses Reveal That Staphylococcus aureus Antibiotic Resistance Factor HmrA Is a Zinc-dependent Endopeptidase Crystal Structures of Bacterial Peptidoglycan Amidase AmpD and an Unprecedented Activation Mechanism Structural basis for multifunctional roles of mammalian aminopeptidase N Multiple stable conformations account for reversible concentration-dependent oligomerization and autoinhibition of a metamorphic metallopeptidase Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection Inhibition mechanism and model of an angiotensin I-converting enzyme (ACE)-inhibitory hexapeptide from yeast (Saccharomyces cerevisiae)A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets Interaction of severe acute respiratory syndrome-coronavirus and NL63 coronavirus spike proteins with angiotensin converting enzyme-2.The role of Tyr605 and Ala607 of thimet oligopeptidase and Tyr606 and Gly608 of neurolysin in substrate hydrolysis and inhibitor binding Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE.Structure, Function, and Evolution of Coronavirus Spike Proteins.Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure.Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry.Prediction of off-target effects on angiotensin-converting enzyme 2.ACE for all - a molecular perspective Angiotensin converting enzyme (ACE) and ACE2 bind integrins and ACE2 regulates integrin signalling.Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17β-oestradiol-dependent and sex chromosome-independent.Allosteric inhibition of the neuropeptidase neurolysin.Cross-crystal averaging with search models to improve molecular replacement phases.ACE2/ANG-(1-7)/Mas pathway in the brain: the axis of good.Receptor recognition mechanisms of coronaviruses: a decade of structural studies.Species-specific inhibitor sensitivity of angiotensin-converting enzyme 2 (ACE2) and its implication for ACE2 activity assays Angiotensin-converting enzyme 2: the first decade.Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system.Biosynthetic pathways and the role of the MAS receptor in the effects of Angiotensin-(1-7) in smooth muscles.Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus Structure of testis ACE glycosylation mutants and evidence for conserved domain movement.Antivirals and antiviral strategies.Evidence for ACE2-utilizing coronaviruses (CoVs) related to severe acute respiratory syndrome CoV in bats.

P2860

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P2860

ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis

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2004 nî lūn-bûn

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P2093

Bart Staker

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David Williams

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Dominic Ryan

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Jin Tang

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Martin Fisher

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Michael A Patane

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Michael W Pantoliano

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Natalie A Dales

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Paul Towler

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Saurabh Menon

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P2860

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

Crystal structure of the human angiotensin-converting enzyme-lisinopril complex

Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning

The Protein Data Bank

A database of macromolecular motions

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structure of neurolysin reveals a deep channel that limits substrate access

Crystal structure of a novel carboxypeptidase from the hyperthermophilic archaeon Pyrococcus furiosus

Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis

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17996-8007

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10.1074/JBC.M311191200

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17

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279

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14754895

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