A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator - sprookjes - yvandenbroek - TriplyDB

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator

http://www.wikidata.org/entity/Q27644049

about

Post-translational modifications of the progesterone receptors The X-ray Structure of RU486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction Structural Basis for Agonism and Antagonism for a Set of Chemically Related Progesterone Receptor Modulators X-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11 -Substituted Steroids Kaempferol Exhibits Progestogenic Effects in Ovariectomized Rats Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled.A new strategy for selective targeting of progesterone receptor with passive antagonists.Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation.Structural basis for computational screening of non-steroidal androgen receptor ligands.Glucocorticoid receptor cofactors as therapeutic targets.Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer.Tracking progesterone receptor-mediated actions in breast cancer In silico discovery of androgen receptor antagonists with activity in castration resistant prostate cancer Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications.Proinflammatory and profibrotic mediators: principal effectors of leiomyoma development as a fibrotic disorder.Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters.Molecular modeling on structure-function analysis of human progesterone receptor modulators.Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry.Structural and functional analysis of domains of the progesterone receptor.Ulipristal Acetate Inhibits Progesterone Receptor Isoform A-Mediated Human Breast Cancer Proliferation and BCl2-L1 Expression.Exploring Flexibility of Progesterone Receptor Ligand Binding Domain Using Molecular Dynamics.Novel, orally active selective progesterone receptor modulator CP8947 inhibits leiomyoma cell proliferation without adversely affecting endometrium or myometrium.Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies Progesterone receptor action in leiomyoma and endometrial cancer.Effects of antiprogestins on the uterus.Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin.Epigenetics of endometriosis.Recent patent trends in the field of progesterone receptor agonists and modulators.Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor.Structure of the glucocorticoid receptor, a flexible protein that can adapt to different ligands.Nuclear hormone receptor co-repressors: structure and function.New trends for the medical treatment of endometriosis.Lessons learned from the preclinical drug discovery of asoprisnil and ulipristal for non-surgical treatment of uterine leiomyomas.Recent advances in structure of progestins and their binding to progesterone receptors.Experimental treatments of endometriosis.An overview of early drug development for endometriosis.Anti-Tumoral Effects of Anti-Progestins in a Patient-Derived Breast Cancer Xenograft Model.Genomic and Nongenomic Effects of Mifepristone at the Cardiovascular Level: A Review.Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation.

P2860

Q27010251-C3E7E20F-59E3-466C-8D0C-3BB24882E7AB Q27654859-AAC4EE3E-F6B1-4FA8-B7AA-E75B5B3222AC Q27662827-F210A42D-89F4-41DA-945B-70A0AAF0EAAB Q27671815-196279C2-ABC7-44E0-AA5F-1074F1781249 Q27678748-050FD722-EF89-445F-BB48-903348054959 Q28260010-D8E4F1B8-CCFA-474B-9D7F-F3A4AC75FB3B Q33545556-AB284A3A-73C1-4617-8692-DF81B201FCA9 Q33633141-910A20B0-6600-495C-B7EF-D6078E209DB4 Q34206915-0CC95C7F-45F1-4838-90D7-F255DBA344C5 Q34289773-8F1E2E60-AE1B-4879-9531-863E0E6F8D74 Q34311390-3A21E619-7AAA-4EA3-8DF9-0C51FF880AA2 Q34321877-B8BD85A4-B93C-460B-810B-1B59AE04E9F6 Q34388848-3DA60A14-75B9-4C86-B920-AC46C65EE163 Q34424735-0DAF9BE1-E6B5-4A18-AABF-05D32152171B Q34437666-5B2C63D0-7EAD-4892-8F8D-CE70916151EC Q34674982-7DD86B9E-1E03-4214-B150-FA6F62B5DBA7 Q35181201-8C3F33E1-DF24-4790-A1AB-7CC6F258A105 Q35185298-787E7212-1A38-40CD-8AFD-1571C7CE999A Q35372743-5ECD88CB-E520-49AB-9F73-4B399D2690AE Q35624126-95F67E4A-375C-416C-A314-365CA69BC66D Q35810608-DB17A854-B166-4752-AA05-1606A6005146 Q36185635-2342556E-ED0E-4FD3-8A58-9D0FFB3D3070 Q36620524-1D34E08F-FF4E-42B2-96ED-E97292A353A3 Q37186618-A7F197EE-4A7A-4150-B00A-033107975832 Q37338412-9AC29813-415E-42D8-9230-DF12312487FD Q37346109-0A2207B1-03D6-4C70-B2B0-8AE7545B0E88 Q37364468-C5E2C198-4F6E-41A6-8027-9F3582CCD370 Q37571067-E7188BCF-65B2-417B-9E5D-82A337C0D085 Q37604376-DCCDD4FE-EA04-42F8-8CC7-BA509CD0B968 Q37608465-0E6B34F1-3455-463F-937A-9C2B4EDEC5E1 Q37718094-3DA77ED3-B227-4175-A698-26C2E9573B27 Q37934059-837E17C5-E96C-4F1B-9B96-4337067B344F Q38008481-A79F8CC8-6667-4247-9B03-B553FA6BA816 Q38014487-D13F9272-46A3-442B-813D-CA28EA9CB574 Q38199191-8C6323DE-E5C6-43B0-B2DD-47DBA50F18E1 Q38575273-9D065F3D-75C3-4FEE-A485-5912A15D0D1A Q38653393-C7EE2D3C-FD5C-4912-8C5C-40993F470D74 Q38789039-5FDF92A9-E4B7-4001-8359-4FEF1EE44025 Q38966345-F2685437-6260-4DE1-82E4-109ED2730FCB Q39884872-6E97CF78-EB6F-45FD-8BEE-B255D7D4A266

P2860

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator

http://www.wikidata.org/entity/Q27644049

description

2007 nî lūn-bûn

@nan

2007 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

A structural and in vitro char ...... rogesterone receptor modulator

@ast

A structural and in vitro char ...... rogesterone receptor modulator

@en

A structural and in vitro char ...... rogesterone receptor modulator

@nl

type

label

A structural and in vitro char ...... rogesterone receptor modulator

@ast

A structural and in vitro char ...... rogesterone receptor modulator

@en

A structural and in vitro char ...... rogesterone receptor modulator

@nl

prefLabel

A structural and in vitro char ...... rogesterone receptor modulator

@ast

A structural and in vitro char ...... rogesterone receptor modulator

@en

A structural and in vitro char ...... rogesterone receptor modulator

@nl

P1433

Q27644049-CC2460D2-0591-4CDD-B1F0-9709006E1476

P1476

Q27644049-EFE49948-F430-4E20-92F3-592984E5B812

P2093

Q27644049-070B16D9-12E0-445C-B323-5D608433E0D2

Q27644049-0DD169CB-D76A-4E30-ABBF-4A58FB54A4E1

Q27644049-1A55E547-340D-41E8-9805-A994ABD5B6E6

Q27644049-54520295-4987-4FE6-907B-76B8320C4F8C

Q27644049-835B2607-6BFD-4529-8441-83EE42F15D53

Q27644049-8A89BDDF-85FB-4E74-AB05-B959F4A9F8FA

Q27644049-969EAE58-5628-44B2-8605-05F7CE248625

Q27644049-C3CE95E3-AE0C-4F71-BE66-0469949DCC52

Q27644049-C471A60B-F7B3-4779-A115-CC7F0F9B789B

Q27644049-EEE05BC7-E902-4DBD-BF8C-3ADADD4CA617

P304

Q27644049-5726CE3D-572C-49D6-8842-3B83A1029171

P31

Q27644049-57F1C938-4541-42B7-B227-FE3AE042ED05

P3181

Q27644049-D2F6DC74-8988-40FC-9921-D6F828F2F500

P356

Q27644049-74349EC7-AE12-4297-BC9D-5E553CFE6CA6

P433

Q27644049-086A3975-6614-4C6A-BEEB-A30A9EAD1936

P478

Q27644049-E0A6A920-5AAF-4085-82DF-B6DE2A4B3841

P50

Q27644049-F20DDF8C-17C4-41AC-B5BD-5F4FCD91169F

P577

Q27644049-FDF9B6AF-1FDA-48BC-AAA8-EC4D5D845183

P5875

Q27644049-FAEFFEC2-2D05-4BB7-911F-D7F2F471671F

P698

Q27644049-D06019F1-E942-4DF4-93FD-87A6AD60EE0C

P3181

P356

P1433

Molecular Endocrinology

P1476

A structural and in vitro char ...... rogesterone receptor modulator

@en

P2093

Anthony C Sulpizio

http://www.w3.org/2001/XMLSchema#string

Charlene Wu

http://www.w3.org/2001/XMLSchema#string

Eugene L Stewart

http://www.w3.org/2001/XMLSchema#string

Eugene T Grygielko

http://www.w3.org/2001/XMLSchema#string

Jeffrey D Bray

http://www.w3.org/2001/XMLSchema#string

Kevin P Madauss

http://www.w3.org/2001/XMLSchema#string

Nicholas J Laping

http://www.w3.org/2001/XMLSchema#string

Scott K Thompson

http://www.w3.org/2001/XMLSchema#string

Steve A Short

http://www.w3.org/2001/XMLSchema#string

Su-Jun Deng

http://www.w3.org/2001/XMLSchema#string

P304

1066-1081

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1905631

http://www.w3.org/2001/XMLSchema#string

P356

10.1210/ME.2006-0524

http://www.w3.org/2001/XMLSchema#string

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

21

http://www.w3.org/2001/XMLSchema#string

P50

P577

2007-03-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6451359

http://www.w3.org/2001/XMLSchema#string

P698

17356170

http://www.w3.org/2001/XMLSchema#string