Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
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Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymesThe molecular biology, biochemistry, and physiology of human steroidogenesis and its disordersAtomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplAP450cin Active Site Water: Implications for Substrate Binding and Solvent AccessibilityCrystal Structures and Functional Characterization of Wild-Type CYP101D1 and Its Active Site MutantsStructure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE(CYP152L1) from theJeotgalicoccussp. 8456 BacteriumRevisiting the mechanism of dioxygen activation in soluble methane monooxygenase from M. capsulatus (Bath): evidence for a multi-step, proton-dependent reaction pathway.Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetyleneKinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps.Changing the regioselectivity of a P450 from C15 to C11 hydroxylation of progesterone.Involvement of a cytochrome P450 monooxygenase in thaxtomin A biosynthesis by Streptomyces acidiscabies.Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide. Implication for its nitric oxide reduction mechanism.Heme enzyme structure and function.Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenesNew insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Mechanistic enzymology of oxygen activation by the cytochromes P450.P450 structures and oxidative metabolism of xenobiotics.Thr302 is the site for the covalent modification of human cytochrome P450 2B6 leading to mechanism-based inactivation by tert-butylphenylacetyleneIdentification of a functional water channel in cytochrome P450 enzymes.Isolation and sequence of a cDNA encoding the Jerusalem artichoke cinnamate 4-hydroxylase, a major plant cytochrome P450 involved in the general phenylpropanoid pathway.Unusual properties of the cytochrome P450 superfamily.Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdomsEfficient catalytic turnover of cytochrome P450(cam) is supported by a T252N mutation.Valence tautomerism in synthetic models of cytochrome P450.Oxygen activation by cytochrome P450 monooxygenaseS K-edge XAS and DFT calculations on cytochrome P450: covalent and ionic contributions to the cysteine-Fe bond and their contribution to reactivity.Role of the highly conserved threonine in cytochrome P450 2E1: prevention of H2O2-induced inactivation during electron transferActive site proton delivery and the lyase activity of human CYP17A1.Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.Conformational plasticity and structure/function relationships in cytochromes P450.CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding.Spectroscopic and Kinetic Evidence for the Crucial Role of Compound 0 in the P450cam -Catalyzed Hydroxylation of Camphor by Hydrogen Peroxide.Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzymeCatalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE.The active site structure of methane monooxygenase is closely related to the binuclear iron center of ribonucleotide reductase.Mutation THR-185 ILE is associated with corticosterone methyl oxidase deficiency type II.Investigating the roles of T224 and T232 in the oxidation of cinnamaldehyde catalyzed by myxobacterial CYP260B1.Structural characterization of CYP260A1 from Sorangium cellulosum to investigate the 1α-hydroxylation of a mineralocorticoid.Novel CYP11B2 mutation causing aldosterone synthase (P450c11AS) deficiency.
P2860
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P2860
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
description
1991 nî lūn-bûn
@nan
1991 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
name
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
@ast
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
@en
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
@nl
type
label
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
@ast
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
@en
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
@nl
prefLabel
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
@ast
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
@en
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
@nl
P2093
P356
P1433
P1476
Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
@en
P2093
P304
P356
10.1021/BI00112A008
P407
P577
1991-12-03T00:00:00Z