Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state

Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state

Item
http://www.wikidata.org/entity/Q27644481
A conserved protonation-dependent switch controls drug binding in the Abl kinaseA conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulationInhibitors that stabilize a closed RAF kinase domain conformation induce dimerizationMutations in the catalytic loop HRD motif alter the activity and function of Drosophila Src64Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modificationIdentification of RIP1 kinase as a specific cellular target of necrostatinsOptimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.A helix scaffold for the assembly of active protein kinasesAccurate calculation of mutational effects on the thermodynamics of inhibitor binding to p38α MAP kinase: a combined computational and experimental studyStructural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.ProKinO: a unified resource for mining the cancer kinome.The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.A dynamically coupled allosteric network underlies binding cooperativity in Src kinase.Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone.
P2860

Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state

Item
http://www.wikidata.org/entity/Q27644481
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
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2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Mutagenesis of p38alpha MAP ki ...... reveals a novel DFG-OUT state
@ast
Mutagenesis of p38alpha MAP ki ...... reveals a novel DFG-OUT state
@en
Mutagenesis of p38alpha MAP ki ...... reveals a novel DFG-OUT state
@nl
type
label
Mutagenesis of p38alpha MAP ki ...... reveals a novel DFG-OUT state
@ast
Mutagenesis of p38alpha MAP ki ...... reveals a novel DFG-OUT state
@en
Mutagenesis of p38alpha MAP ki ...... reveals a novel DFG-OUT state
@nl
prefLabel
Mutagenesis of p38alpha MAP ki ...... reveals a novel DFG-OUT state
@ast
Mutagenesis of p38alpha MAP ki ...... reveals a novel DFG-OUT state
@en
Mutagenesis of p38alpha MAP ki ...... reveals a novel DFG-OUT state
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Mutagenesis of p38alpha MAP ki ...... reveals a novel DFG-OUT state
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698