Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans
about
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 systemInsights into cytokine-receptor interactions from cytokine engineeringCrystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentationThe shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapyA synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interactionNovel human interleukin-15 agonistsInterleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune moleculesCharacterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rα cytokine compared to IL-15 monomer.Mechanistic model of natural killer cell proliferative response to IL-15 receptor stimulationIL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation.Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity.Structural biology of shared cytokine receptors.Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co-evolved with this third family member, all sharing binding motifs for IL-15Rα.Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway.Interleukin-15 in the treatment of cancer.Enhancement of the inhibitory effect of an IL-15 antagonist peptide by alanine scanning.Characterization of recombinant human IL-15 deamidation and its practical elimination through substitution of asparagine 77.An efficient platform for screening expression and crystallization of glycoproteins produced in human cells.Pressuromodulation at the cell membrane as the basis for small molecule hormone and peptide regulation of cellular and nuclear functionA conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane.Discovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy.
P2860
Q24301975-7EE0FAD4-F225-4191-A7B6-60FF1D73A3B1Q24310081-A3FFEE94-22B6-4CD8-9466-00D6EBA5EAA7Q26852703-0F8C539B-540D-4C9C-B94F-14F9825586E6Q27648832-98B9C851-69F4-4330-B191-0BD2B404BB8BQ28088784-D8983151-DA9F-47FC-9551-AE37A4A5323EQ30654313-4D855285-7EEC-4E0C-9D96-A066B2098FE8Q33623266-3117FD22-C1F7-4EF5-911C-AAF9C0CF2C78Q34626998-763E3A37-74F4-474D-BE69-01C23502B395Q34708192-45083414-C7FA-43FF-9EBA-0904DB6A31B4Q34998162-49DA8A3D-5943-4F31-B43D-386491645D0BQ36640049-4430D3B6-65CD-4C08-A842-8DDC57F380C2Q37214209-5AB0E7FC-D822-4660-A836-D69C0412F5D6Q37279324-5C70C2F4-D59E-4746-A222-9C9F959B36BCQ37488866-F480F95A-F61A-43A5-8507-A81D571455A1Q38050490-209CE222-3128-4BE1-825A-735B3C1A34DEQ38264072-8653331E-33BE-48A3-AC3C-D755F17B8C23Q39448215-8DE567B4-5753-41AC-933E-EF41B6B37EBEQ39456212-ADE186DD-2A35-45F5-958F-FE0DF8AB659DQ39859955-51CF24CF-299C-437D-AD08-5912E5DD9C9AQ42153567-230676AA-7E13-4A4D-9E79-9E8808C92E45Q48179107-64A51CDE-812E-4517-A7F6-CE92918DBD2BQ55229734-71CD3D5E-3FFF-4FF5-AFEE-1996D52C2E27
P2860
Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Crystal structure of the IL-15 ...... ceptor unit presented in trans
@ast
Crystal structure of the IL-15 ...... ceptor unit presented in trans
@en
Crystal structure of the IL-15 ...... ceptor unit presented in trans
@nl
type
label
Crystal structure of the IL-15 ...... ceptor unit presented in trans
@ast
Crystal structure of the IL-15 ...... ceptor unit presented in trans
@en
Crystal structure of the IL-15 ...... ceptor unit presented in trans
@nl
prefLabel
Crystal structure of the IL-15 ...... ceptor unit presented in trans
@ast
Crystal structure of the IL-15 ...... ceptor unit presented in trans
@en
Crystal structure of the IL-15 ...... ceptor unit presented in trans
@nl
P2093
P2860
P356
P1433
P1476
Crystal structure of the IL-15 ...... ceptor unit presented in trans
@en
P2093
Chiharu Hayashi
Hirofumi Kai
Mami Chirifu
Sachiko Toma
Shinji Ikemizu
Simon J Davis
Teruya Nakamura
Tsuyoshi Shuto
Yuriko Yamagata
P2860
P304
P356
10.1038/NI1492
P407
P577
2007-09-01T00:00:00Z