Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR
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Role of phosphatidic acid in the coupling of the ERK cascade.Rapamycin and mTOR kinase inhibitorsRegulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane TargetingLipid biology of breast cancerCharacterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATIONHigh Resolution NMR-based Model for the Structure of a scFv-IL-1 Complex: POTENTIAL FOR NMR AS A KEY TOOL IN THERAPEUTIC ANTIBODY DESIGN AND DEVELOPMENTConservation of Functional Sites on Interleukin-6 and Implications for Evolution of Signaling Complex Assembly and Therapeutic InterventionStructure and Interactions of the Human Programmed Cell Death 1 ReceptorMechanosensitive Molecular Networks Involved in Transducing Resistance Exercise-Signals into Muscle Protein AccretionBiophysical and molecular-dynamics studies of phosphatidic acid binding by the Dvl-2 DEP domain.Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdomIntracellular parasitism with Toxoplasma gondii stimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1.Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity.Rapamycin for treating Tuberous sclerosis and Autism spectrum disordersPhosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway.Putting the pH into phosphatidic acid signalingPhospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerLongevity, aging and rapamycin.Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells.Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway.Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid.Interaction of the transactivation domain of B-Myb with the TAZ2 domain of the coactivator p300: molecular features and properties of the complex.Activating mutations of TOR (target of rapamycin).Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1).Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect.RNA sequencing identifies upregulated kyphoscoliosis peptidase and phosphatidic acid signaling pathways in muscle hypertrophy generated by transgenic expression of myostatin propeptideRapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid.Phospholipase D: enzymology, functionality, and chemical modulationDual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin.Exercise and amino acid anabolic cell signaling and the regulation of skeletal muscle massDiacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1The Enigma of Rapamycin Dosage.Phosphatidic acid and lipid-sensing by mTORNMR- and circular dichroism-monitored lipid binding studies suggest a general role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK)Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling.Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family.Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis.Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
P2860
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P2860
Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural characterization of ...... le-mediated regulation of mTOR
@ast
Structural characterization of ...... le-mediated regulation of mTOR
@en
Structural characterization of ...... le-mediated regulation of mTOR
@nl
type
label
Structural characterization of ...... le-mediated regulation of mTOR
@ast
Structural characterization of ...... le-mediated regulation of mTOR
@en
Structural characterization of ...... le-mediated regulation of mTOR
@nl
prefLabel
Structural characterization of ...... le-mediated regulation of mTOR
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Structural characterization of ...... le-mediated regulation of mTOR
@en
Structural characterization of ...... le-mediated regulation of mTOR
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structural characterization of ...... le-mediated regulation of mTOR
@en
P2093
P2860
P2888
P304
P3181
P356
10.1038/SJ.ONC.1210693
P407
P577
2007-08-06T00:00:00Z
P5875
P6179
1046096765