about
Increased Diels-Alderase activity through backbone remodeling guided by Foldit players.Emerging Vaccine TechnologiesStructure of an isolated unglycosylated antibody CH2 domainMetal-binding loop length and not sequence dictates structureAlteration of enzyme specificity by computational loop remodeling and designHigh-resolution structure prediction of a circular permutation loopIncreasing Sequence Diversity with Flexible Backbone Protein Design: The Complete Redesign of a Protein Hydrophobic CoreStructural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent proteinC-terminal β-strand swapping in a consensus-derived fibronectin Type III scaffoldN-terminal β-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactionsMulti-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibilityImprovements to robotics-inspired conformational sampling in rosettaAssessment of flexible backbone protein design methods for sequence library prediction in the therapeutic antibody Herceptin-HER2 interfacePredicting the tolerated sequences for proteins and protein interfaces using RosettaBackrub flexible backbone designShortening a loop can increase protein native state entropy.Engineering protein stability with atomic precision in a monomeric miniprotein.A self-organizing algorithm for modeling protein loops.The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein designSpecificity in computational protein designAchievements and Challenges in Computational Protein Design.Validating a Coarse-Grained Potential Energy Function through Protein Loop Modelling.Experimental library screening demonstrates the successful application of computational protein design to large structural ensemblesAnchored design of protein-protein interfaces.RosettaRemodel: a generalized framework for flexible backbone protein design.Protein loop closure using orientational restraints from NMR dataThree-residue loop closure in proteins: a new kinematic method reveals a locus of connected loop conformations.Redesign of the PAK1 autoinhibitory domain for enhanced stability and affinity in biosensor applications.Models to Approximate the Motions of Protein Loops.Fibronectin type III domains engineered to bind CD40L: cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of two complexesComputational design of affinity and specificity at protein-protein interfacesDesign of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences.Design of symmetric TIM barrel proteins from first principles.Computational design and experimental verification of a symmetric protein homodimer.Structural Determinants of Misfolding in Multidomain ProteinsComputer-aided antibody design.Dissecting the metal selectivity of MerR monovalent metal ion sensors in Salmonella.The importance of slow motions for protein functional loops.Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension.Coexpression of human alpha- and circularly permuted beta-globins yields a hemoglobin with normal R state but modified T state propertiesX-ray vs. NMR structures as templates for computational protein design.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
High-resolution design of a protein loop
@ast
High-resolution design of a protein loop
@en
High-resolution design of a protein loop
@nl
type
label
High-resolution design of a protein loop
@ast
High-resolution design of a protein loop
@en
High-resolution design of a protein loop
@nl
prefLabel
High-resolution design of a protein loop
@ast
High-resolution design of a protein loop
@en
High-resolution design of a protein loop
@nl
P2860
P3181
P356
P1476
High-resolution design of a protein loop
@en
P2093
Huanchen Wang
Xiaozhen Hu
P2860
P304
P3181
P356
10.1073/PNAS.0707977104
P407
P577
2007-11-06T00:00:00Z