Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors
about
Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart FailureChemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosisToward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †Iodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis InhibitorsToward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †How Much Binding Affinity Can be Gained by Filling a Cavity?A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and CytotoxicityChemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasmaTrapping of palindromic ligands within native transthyretin prevents amyloid formationAromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent ConjugateTafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascadeBifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensorsFluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learnStilbene Vinyl Sulfonamides as Fluorogenic Sensors of and Traceless Covalent Kinetic Stabilizers of Transthyretin That Prevent AmyloidogenesisUnderstanding the microscopic binding mechanism of hydroxylated and sulfated polybrominated diphenyl ethers with transthyretin by molecular docking, molecular dynamics simulations and binding free energy calculations.Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidosesA stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate.An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis.A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.Transthyretin: the servant of many masters.A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies.Halogen bonding (X-bonding): a biological perspective.Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.Current and future treatment of amyloid diseases.Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation.A novel strategy for the construction of substituted benzoxazoles via a tandem oxidative process.Stabilization of protein-protein interactions in drug discovery.S8 -Mediated Cyclization of 2-Aminophenols/thiophenols with Arylmethyl Chloride: Approach to Benzoxazoles and Benzothiazoles.Understanding and Ameliorating the TTR AmyloidosesTafamidis (Vyndaqel): A Light for FAP Patients
P2860
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P2860
Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Biochemical and structural eva ...... tin amyloidogenesis inhibitors
@ast
Biochemical and structural eva ...... tin amyloidogenesis inhibitors
@en
Biochemical and structural eva ...... tin amyloidogenesis inhibitors
@nl
type
label
Biochemical and structural eva ...... tin amyloidogenesis inhibitors
@ast
Biochemical and structural eva ...... tin amyloidogenesis inhibitors
@en
Biochemical and structural eva ...... tin amyloidogenesis inhibitors
@nl
prefLabel
Biochemical and structural eva ...... tin amyloidogenesis inhibitors
@ast
Biochemical and structural eva ...... tin amyloidogenesis inhibitors
@en
Biochemical and structural eva ...... tin amyloidogenesis inhibitors
@nl
P356
P1476
Biochemical and structural eva ...... tin amyloidogenesis inhibitors
@en
P2093
Stephen Connelly
Steven M Johnson
P304
P356
10.1021/JM0708735
P407
P577
2008-01-24T00:00:00Z