Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs
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Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patientsA bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosisRegulation of small GTPases by GEFs, GAPs, and GDIsInternational Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptorsp63RhoGEF: a new switch for G(q)-mediated activation of smooth muscle.Function and regulation of the Rho guanine nucleotide exchange factor TrioRecognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEFStructural Determinants of G-protein Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)Structure-function study of the N-terminal domain of exocyst subunit Sec3Structural basis for the specific inhibition of heterotrimeric Gq protein by a small moleculeKinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling ComplexIdentification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain ComplexStructural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq ComplexCrystal structure of mouse RhoA:GTPγS complex in a centered latticeA bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteinsStructural determinants involved in the formation and activation of G protein betagamma dimers.The phospholipase C isozymes and their regulationKalrn plays key roles within and outside of the nervous systemRegulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular locationStrike a pose: Gαq complexes at the membranep63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.TRPC Channels Mediate a Muscarinic Receptor-Induced Afterdepolarization in Cerebral Cortex.On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase CβKinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein GαqStimulation of α1a adrenergic receptors induces cellular proliferation or antiproliferative hypertrophy dependent solely on agonist concentrationHigh-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assayOverexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma.Novel insights into G protein and G protein-coupled receptor signaling in cancerStructure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6.G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR).Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.Kalrn promoter usage and isoform expression respond to chronic cocaine exposureMixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cellsGα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signalingLysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears.
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P2860
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs
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2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs
@ast
Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs
@en
Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs
@nl
type
label
Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs
@ast
Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs
@en
Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs
@nl
prefLabel
Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs
@ast
Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs
@en
Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs
@en
P2093
Aruna Shankaranarayanan
Cassandra Coco
Chris R Evelyn
Christiane Vettel
Doris Baltus
John J G Tesmer
Marc Ridilla
Mark R Nance
Richard R Neubig
Susanne Lutz
P2860
P304
P3181
P356
10.1126/SCIENCE.1147554
P407
P577
2007-12-21T00:00:00Z