Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding
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Metabolic engineering of cofactor F420 production in Mycobacterium smegmatisUnexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteriaChemical approaches to detect and analyze protein sulfenic acidsIdentification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradationThe Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V BiosynthesisStructure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8Rv2074 is a novel F420 H2 -dependent biliverdin reductase in Mycobacterium tuberculosisRv0132c of Mycobacterium tuberculosis encodes a coenzyme F420-dependent hydroxymycolic acid dehydrogenaseMolecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis.Mycobacterial F420H2-Dependent Reductases Promiscuously Reduce Diverse Compounds through a Common Mechanism.F420H2-dependent degradation of aflatoxin and other furanocoumarins is widespread throughout the actinomycetalesComparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver.Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis.Impact of Fgd1 and ddn diversity in Mycobacterium tuberculosis complex on in vitro susceptibility to PA-824.Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosisPhysiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions.F420H2 Is Required for Phthiocerol Dimycocerosate Synthesis in Mycobacteria.The redox cofactor F420 protects mycobacteria from diverse antimicrobial compounds and mediates a reductive detoxification system.The nitroimidazooxazines (PA-824 and analogs): structure-activity relationship and mechanistic studies.New treatment options for multidrug-resistant tuberculosis.Production of recombinant proteins in Mycobacterium smegmatis for structural and functional studies.Mechanistic insights into F420-dependent glucose-6-phosphate dehydrogenase using isotope effects and substrate inhibition studies.Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis.Discovery and characterization of an F420-dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1.Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria.Cofactor Tail Length Modulates Catalysis of Bacterial F420-Dependent OxidoreductasesCharacterization of the frhAGB-encoding hydrogenase from a non-methanogenic hyperthermophilic archaeon.Fgd1 reactivates F420Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824).Mechanism(s) of action of heavy metals to investigate the regulation of plastidic glucose-6-phosphate dehydrogenase
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P2860
Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Crystal structures of F420-dep ...... coenzyme and substrate binding
@ast
Crystal structures of F420-dep ...... coenzyme and substrate binding
@en
Crystal structures of F420-dep ...... coenzyme and substrate binding
@nl
type
label
Crystal structures of F420-dep ...... coenzyme and substrate binding
@ast
Crystal structures of F420-dep ...... coenzyme and substrate binding
@en
Crystal structures of F420-dep ...... coenzyme and substrate binding
@nl
prefLabel
Crystal structures of F420-dep ...... coenzyme and substrate binding
@ast
Crystal structures of F420-dep ...... coenzyme and substrate binding
@en
Crystal structures of F420-dep ...... coenzyme and substrate binding
@nl
P2860
P50
P921
P356
P1476
Crystal structures of F420-dep ...... coenzyme and substrate binding
@en
P2860
P304
P356
10.1074/JBC.M801854200
P407
P577
2008-06-20T00:00:00Z