An Unusual Allosteric Mobility of the C-Terminal Helix of a High-Affinity αL Integrin I Domain Variant Bound to ICAM-5
about
Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1Structure of Collagen Receptor Integrin 1I Domain Carrying the Activating Mutation E317AStable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug DesignCrystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesionsComplex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies.Conformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1Why integrin as a primary target for imaging and therapy.Early chordate origin of the vertebrate integrin αI domains.Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loopInteractions between ICAM-5 and β1 integrins regulate neuronal synapse formationLeukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.Metazoans evolved by taking domains from soluble proteins to expand intercellular communication network.Regulation of integrin activity and signallingSubcellular localization of intercellular adhesion molecule-5 (telencephalin) in the visual cortex is not developmentally regulated in the absence of matrix metalloproteinase-9.Rolling cell adhesionThe leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties.Intrinsic local destabilization of the C-terminus predisposes integrin α1 I domain to a conformational switch induced by collagen binding.NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domainNeuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia.A pivotal role for a conserved bulky residue at the α1-helix of the αI integrin domain in ligand binding.Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1.Novel aspects in the regulation of the leukocyte adhesion cascade.
P2860
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P2860
An Unusual Allosteric Mobility of the C-Terminal Helix of a High-Affinity αL Integrin I Domain Variant Bound to ICAM-5
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
An Unusual Allosteric Mobility ...... Domain Variant Bound to ICAM-5
@ast
An Unusual Allosteric Mobility ...... Domain Variant Bound to ICAM-5
@en
An Unusual Allosteric Mobility ...... Domain Variant Bound to ICAM-5
@nl
type
label
An Unusual Allosteric Mobility ...... Domain Variant Bound to ICAM-5
@ast
An Unusual Allosteric Mobility ...... Domain Variant Bound to ICAM-5
@en
An Unusual Allosteric Mobility ...... Domain Variant Bound to ICAM-5
@nl
prefLabel
An Unusual Allosteric Mobility ...... Domain Variant Bound to ICAM-5
@ast
An Unusual Allosteric Mobility ...... Domain Variant Bound to ICAM-5
@en
An Unusual Allosteric Mobility ...... Domain Variant Bound to ICAM-5
@nl
P2093
P2860
P50
P1433
P1476
An unusual allosteric mobility ...... domain variant bound to ICAM-5
@en
P2093
Jia-huai Wang
Jin-huan Liu
Jose M Casasnovas
Moonsoo Jin
Timothy A Springer
P2860
P304
P356
10.1016/J.MOLCEL.2008.06.022
P577
2008-08-01T00:00:00Z