Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors
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Bioretrosynthetic construction of a didanosine biosynthetic pathwayHeat shock protein 90 inhibition: rationale and clinical potential.New C-19-modified geldanamycin derivatives: synthesis, antitumor activities, and physical properties study.Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.Metabolic engineering for the production of natural products.Biosynthesis of 3,5-AHBA-derived natural products.Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesisAntimicrobial activities of jadomycin B and structurally related analogues.Design, synthesis, and biological evaluation of conformationally constrained cis-amide Hsp90 inhibitors.Molecular basis for the actions of Hsp90 inhibitors and cancer therapy.Natural products and Pharma 2011: strategic changes spur new opportunities.Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity.Industrial natural product chemistry for drug discovery and development.New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus.Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?Genetic regulation and manipulation for natural product discovery.New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90.Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges.Identification of 6-demethoxy-6-methylgeldanamycin and its implication of geldanamycin biosynthesis.Natural product analogues: towards a blueprint for analogue-focused synthesis.Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors.Divergolide congeners illuminate alternative reaction channels for ansamycin diversification.Myxobacteria: natural pharmaceutical factories.Reaction design, discovery, and development as a foundation to function-oriented synthesis.Site-specific modification of the anticancer and antituberculosis polyether salinomycin by biosynthetic engineering.A new method for rapid identification of ansamycin compounds by inactivating KLM gene clusters in potential ansamycin-producing actinomyces.Identification and Engineering of Post-PKS Modification Bottlenecks for Ansamitocin P-3 Titer Improvement in Actinosynnema pretiosum subsp. pretiosum ATCC 31280.Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.Impact of Microbial Natural Products on Antibacterial Drug Discovery
P2860
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P2860
Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Optimizing natural products by ...... of nonquinone Hsp90 inhibitors
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Optimizing natural products by ...... of nonquinone Hsp90 inhibitors
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Optimizing natural products by ...... of nonquinone Hsp90 inhibitors
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type
label
Optimizing natural products by ...... of nonquinone Hsp90 inhibitors
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Optimizing natural products by ...... of nonquinone Hsp90 inhibitors
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Optimizing natural products by ...... of nonquinone Hsp90 inhibitors
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prefLabel
Optimizing natural products by ...... of nonquinone Hsp90 inhibitors
@ast
Optimizing natural products by ...... of nonquinone Hsp90 inhibitors
@en
Optimizing natural products by ...... of nonquinone Hsp90 inhibitors
@nl
P2093
P356
P1476
Optimizing natural products by ...... of nonquinone Hsp90 inhibitors
@en
P2093
Barrie Wilkinson
Christine J Martin
Gerrard Peck
Laurence Pearl
Lesley S Sheehan
Markus Radzom
Matthew A Gregory
Ming-Qiang Zhang
Mohammad Nur-E-Alam
Nigel J Coates
P304
P356
10.1021/JM8006068
P407
P577
2008-09-25T00:00:00Z