Structural elucidation of a PRP8 core domain from the heart of the spliceosome - sprookjes - yvandenbroek - TriplyDB

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

http://www.wikidata.org/entity/Q27652426

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Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2 Mechanism for Aar2p function as a U5 snRNP assembly factor Crystal structure of Prp8 reveals active site cavity of the spliceosome Structural basis for dual roles of Aar2p in U5 snRNP assembly Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.Spliceosome Structure and Function Two Prp19-like U-box proteins in the MOS4-associated complex play redundant roles in plant innate immunity Prp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptase Functional roles of protein splicing factors.Spliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!Conformational heterogeneity of the protein-free human spliceosomal U2-U6 snRNA complex ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.The spliceosome as ribozyme hypothesis takes a second step.Model systems: how chemical biologists study RNA.Splicing of mRNA precursors: the role of RNAs and proteins in catalysis.Structural insights into RNA splicing.Nucleases: diversity of structure, function and mechanism.The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.Structural analyses of the pre-mRNA splicing machinery Structural studies of the spliceosome: zooming into the heart of the machine.Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.A snRNP's ordered path to maturity.Functions and regulation of the Brr2 RNA helicase during splicing.Crystallization and biochemical characterization of the human spliceosomal Aar2-Prp8(RNaseH) complex.Emerging views about the molecular structure of the spliceosomal catalytic center.An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8.The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.Mechanisms of RNA catalysis.A critical assessment of the utility of protein-free splicing systems.Toggling in the spliceosome.Is the spliceosome a ribonucleoprotein enzyme?Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine.Structural dynamics of the N-terminal domain and the Switch loop of Prp8 during spliceosome assembly and activation.Spliceosome's core exposed

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P2860

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

http://www.wikidata.org/entity/Q27652426

description

2008 nî lūn-bûn

@nan

2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

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Structural elucidation of a PRP8 core domain from the heart of the spliceosome

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Structural elucidation of a PRP8 core domain from the heart of the spliceosome

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type

label

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

@ast

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

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Structural elucidation of a PRP8 core domain from the heart of the spliceosome

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prefLabel

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

@ast

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

@en

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

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Nature Structural & Molecular Biology

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Structural elucidation of a PRP8 core domain from the heart of the spliceosome

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Andrew M Macmillan

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David T Stuart

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Dustin B Ritchie

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Emily M Gesner

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Matthew J Schellenberg

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Sheetal A Raithatha

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1199-205

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scholarly article

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10.1038/NSMB.1505

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11

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15

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2008-11-01T00:00:00Z

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23300958

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1034875878

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18836455

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