Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation - sprookjes - yvandenbroek - TriplyDB

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

http://www.wikidata.org/entity/Q27654261

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Human isoprenoid synthase enzymes as therapeutic targets Chemo-Immunotherapeutic Antimalarials Targeting Isoprenoid Biosynthesis Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate Squalene synthase as a target for Chagas disease therapeutics Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro Resistance-resistant antibiotics Bioorganometallic mechanism of action, and inhibition, of IspH Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line.Tetra- to dodecanuclear oxomolybdate complexes with functionalized bisphosphonate ligands: activity in killing tumor cells Multitarget drug discovery for tuberculosis and other infectious diseases.Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.Polyoxometalates functionalized by bisphosphonate ligands: synthesis, structural, magnetic, and spectroscopic characterizations and activity on tumor cell lines.A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design.Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates.1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.Farnesyl diphosphate synthase inhibitors from in silico screening.Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid.Terpene biosynthesis: modularity rules Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni.In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation Computational insights into binding of bisphosphates to farnesyl pyrophosphate synthase Survey of the year 2009: applications of isothermal titration calorimetry.Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010).Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase.On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge.Targeting Cancer Cells with a Bisphosphonate Prodrug.Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors.In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors

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Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

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Joo Hwan No

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Kyle Bergan

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Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

Coot: model-building tools for molecular graphics

SHELXL: high-resolution refinement

XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells.

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5153-5162

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