Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope - sprookjes - yvandenbroek - TriplyDB

Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope

Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope

http://www.wikidata.org/entity/Q27656096

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Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection Conformational Melding Permits a Conserved Binding Geometry in TCR Recognition of Foreign and Self Molecular Mimics Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.T-cell Receptor Specificity Maintained by Altered Thermodynamics MR1 presents microbial vitamin B metabolites to MAIT cells Lack of heterologous cross-reactivity towards HLA-A*02:01 restricted viral epitopes is underpinned by distinct αβT cell receptor signatures DynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles.How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral Antigens Public TCR use by herpes simplex virus-2-specific human CD8 CTLs.Predicting peptide binding affinities to MHC molecules using a modified semi-empirical scoring function.Degenerate T-cell recognition of peptides on MHC molecules creates large holes in the T-cell repertoire.Naturally processed non-canonical HLA-A*02:01 presented peptides.Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes.Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope.Human Cytomegalovirus variant peptides adapt by decreasing their total coordination upon binding to a T cell receptor T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection.Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses.Dipeptides promote folding and peptide binding of MHC class I molecules Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.The versatility of the αβ T-cell antigen receptor.Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination.Structural and biophysical determinants of αβ T-cell antigen recognition.A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned.Understanding the complexity and malleability of T-cell recognition.Structural and Mechanistic Implications of Rearrangement Frequencies within Human TCRBV Genes.Role of the MHC restriction during maturation of antigen-specific human T cells in the thymus.Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response.Partial Dissociation of Truncated Peptides Influences the Structural Dynamics of the MHCI Binding Groove Immune parameters to consider when choosing T-cell receptors for therapy.Amino-terminal extended peptide single-chain trimers are potent synthetic agonists for memory human CD8+ T cells.Crystallization and preliminary X-ray crystallographic characterization of a public CMV-specific TCR in complex with its cognate antigen.Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies.

P2860

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P2860

Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope

http://www.wikidata.org/entity/Q27656096

description

2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Structural bases for the affin ...... human cytomegalovirus epitope

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Structural bases for the affin ...... human cytomegalovirus epitope

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Structural bases for the affin ...... human cytomegalovirus epitope

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type

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Structural bases for the affin ...... human cytomegalovirus epitope

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Structural bases for the affin ...... human cytomegalovirus epitope

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Structural bases for the affin ...... human cytomegalovirus epitope

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prefLabel

Structural bases for the affin ...... human cytomegalovirus epitope

@ast

Structural bases for the affin ...... human cytomegalovirus epitope

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Structural bases for the affin ...... human cytomegalovirus epitope

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JIMMUNOL.0900556

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Journal of Immunology

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Structural bases for the affin ...... human cytomegalovirus epitope

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Anne Chouquet

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Bérangère Neveu

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Dominique Housset

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Emilie Debeaupuis

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François Legoux

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Jean-Baptiste Reiser

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Klara Echasserieau

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Madalen Le Gorrec

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Marc Bonneville

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Paul Machillot

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430-7

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scholarly article

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2958848

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10.4049/JIMMUNOL.0900556

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1

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183

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Bernard Malissen

Adrien Kissenpfennig

Nicole Thielens

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2009-07-01T00:00:00Z

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26307193

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19542454

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Cytomegalovirus