Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
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New drug target in protozoan parasites: the role of thioredoxin reductaseDihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein CrystallographyInhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallographyBinding to large enzyme pockets: small-molecule inhibitors of trypanothione reductaseThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsTrypanothione reductase: a target protein for a combined in vitro and in silico screening approachPolyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilitiesCross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi.Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase.Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.Identification of potential trypanothione reductase inhibitors among commercially available [Formula: see text]-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking.Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei.Use of clomipramine as chemotherapy of the chronic phase of Chagas disease.Biochemistry and Physiology of Reactive Oxygen Species in Euglena.Glutathione reductase a unique enzyme: molecular cloning, expression and biochemical characterization from the stress adapted C4 plant, Pennisetum glaucum (L.) R. Br.The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities
P2860
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P2860
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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Comparative structural, kineti ...... thione reductase with T. cruzi
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P2860
P50
P921
P1476
Comparative structural, kineti ...... thione reductase with T. cruzi
@en
P2093
Deuan C Jones
Wing-Huen A Chow
P2860
P356
10.1016/J.MOLBIOPARA.2009.09.002
P577
2010-01-01T00:00:00Z