Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

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http://www.wikidata.org/entity/Q27658607
Simple Pseudo-dipeptides with a P2' Glutamate: A NOVEL INHIBITOR FAMILY OF MATRIX METALLOPROTEASES AND OTHER METZINCINSCheminformatics-based drug design approach for identification of inhibitors targeting the characteristic residues of MMP-13 hemopexin domainAn integrated computational approach to rationalize the activity of non-zinc-binding MMP-2 inhibitorsMatrix metalloproteinase inhibitors: a patent review (2011 - 2013).Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.Investigational drugs for the treatment of osteoarthritis.Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.Recent Research Advances in Selective Matrix Metalloproteinase-13 Inhibitors as Anti-Osteoarthritis Agents.Molecular Recognition of the Catalytic Zinc(II) Ion in MMP-13: Structure-Based Evolution of an Allosteric Inhibitor to Dual Binding Mode Inhibitors with Improved Lipophilic Ligand Efficiencies.Strategic targeting of multiple water-mediated interactions: a concise and rational structure-based design approach to potent and selective MMP-13 inhibitorsMerging allosteric and active site binding motifs: de novo generation of target selectivity and potency via natural-product-derived fragments.Probing the S1' site for the identification of non-zinc-binding MMP-2 inhibitors.Current status and future prospects for disease modification in osteoarthritis.Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) - experimental validation in human breast and colon cancer.
P2860

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Item
http://www.wikidata.org/entity/Q27658607
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
Discovery of (pyridin-4-yl)-2H ...... he treatment of osteoarthritis
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Discovery of (pyridin-4-yl)-2H ...... he treatment of osteoarthritis
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Discovery of (pyridin-4-yl)-2H ...... he treatment of osteoarthritis
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type
label
Discovery of (pyridin-4-yl)-2H ...... he treatment of osteoarthritis
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Discovery of (pyridin-4-yl)-2H ...... he treatment of osteoarthritis
@en
Discovery of (pyridin-4-yl)-2H ...... he treatment of osteoarthritis
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prefLabel
Discovery of (pyridin-4-yl)-2H ...... he treatment of osteoarthritis
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Discovery of (pyridin-4-yl)-2H ...... he treatment of osteoarthritis
@en
Discovery of (pyridin-4-yl)-2H ...... he treatment of osteoarthritis
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Discovery of (pyridin-4-yl)-2H ...... he treatment of osteoarthritis
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10.1016/J.BMCL.2009.11.081
P407
P433
P478
P577
P5875
P698
P921