Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel, - sprookjes - yvandenbroek - TriplyDB

Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel,

Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel,

http://www.wikidata.org/entity/Q27664259

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Trendspotting in the Protein Data Bank Structural diversity of eukaryotic membrane cytochrome p450s Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert -Butylphenylacetylene: Insight into Partial Enzymatic Activity Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocket Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins.A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States Preferred binding orientations of phenacetin in CYP1A1 and CYP1A2 are associated with isoform-selective metabolism.The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison.Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.Paramagnetic nuclear magnetic resonance relaxation and molecular mechanics studies of the chloroperoxidase-indole complex: insights into the mechanism of chloroperoxidase-catalyzed regioselective oxidation of indole The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4.Plasticity of CYP2B enzymes: structural and solution biophysical methods.New amphiphiles for membrane protein structural biology.Conformational diversity and ligand tunnels of mammalian cytochrome P450s.A Comparative Study of Molecular Structure, pKa, Lipophilicity, Solubility, Absorption and Polar Surface Area of Some Antiplatelet Drugs.Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis.Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry.Structure and function of cytochromes P450 2B: from mechanism-based inactivators to X-ray crystal structures and back Insights into the role of substrates on the interaction between cytochrome b5 and cytochrome P450 2B4 by NMR.Halogen-π Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity.Use of phenoxyaniline analogs to generate biochemical insights into polybrominated diphenyl ether interaction with CYP2B enzymes.Capturing the photo-signaling state of a photoreceptor in a steady-state fashion by binding a transition metal complex.

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P2860

Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel,

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2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Structures of Cytochrome P450 ...... s Ticlopidine and Clopidogrel,

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Structures of Cytochrome P450 ...... s Ticlopidine and Clopidogrel,

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Arthur G Roberts

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C David Stout

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James R Halpert

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Jyothi C Talakad

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Keiko Maekawa

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Qinghai Zhang

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Sean C Gay

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Wen-Xu Hong

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Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution

Structural and Thermodynamic Consequences of 1-(4-Chlorophenyl)imidazole Binding to Cytochrome P450 2B4 † , ‡

Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,

Detection, delineation, measurement and display of cavities in macromolecular structures

Integration of macromolecular diffraction data

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

Phasercrystallographic software

GROMACS: fast, flexible, and free

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