Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine -synthase - sprookjes - yvandenbroek - TriplyDB

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine -synthase

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine -synthase

http://www.wikidata.org/entity/Q27665916

about

Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteins NO* binds human cystathionine β-synthase quickly and tightly Crystal Structure of a Zinc-dependent D-Serine Dehydratase from Chicken Kidney Crystal Structure of Escherichia coli Diaminopropionate Ammonia-lyase Reveals Mechanism of Enzyme Activation and Catalysis Structural basis of regulation and oligomerization of human cystathionine -synthase, the central enzyme of transsulfuration Dimer–Dimer Interaction of the Bacterial Selenocysteine Synthase SelA Promotes Functional Active-Site Formation and Catalytic Specificity Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases Conformational properties of nine purified cystathionine β-synthase mutants.Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine Pre-steady-state kinetic analysis of enzyme-monitored turnover during cystathionine β-synthase-catalyzed H(2)S generation Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activation.Reversible heme-dependent regulation of human cystathionine β-synthase by a flavoprotein oxidoreductase.Increased transsulfuration mediates longevity and dietary restriction in Drosophila.PLP-dependent H(2)S biogenesis.Upregulation of Cysteine Synthase and Cystathionine β-Synthase Contributes to Leishmania braziliensis Survival under Oxidative Stress.Novel structural arrangement of nematode cystathionine β-synthases: characterization of Caenorhabditis elegans CBS-1.Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense.Allosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthase.Purification, crystallization and preliminary crystallographic analysis of human cystathionine β-synthase.Purification, crystallization and preliminary crystallographic analysis of the full-length cystathionine β-synthase from Apis mellifera Detection of reaction intermediates during human cystathionine β-synthase-monitored turnover and H2S production.Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase.Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine β-Synthase.Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease.Kinetics of reversible reductive carbonylation of heme in human cystathionine β-synthase.Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine β-synthase from Saccharomyces cerevisiae.PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.Monitoring of Endogenous Hydrogen Sulfide in Living Cells Using Surface-Enhanced Raman Scattering.Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine β-synthases.Purification, crystallization and preliminary crystallographic analysis of the CBS-domain protein MJ1004 from Methanocaldococcus jannaschii.Structural characterization and functional analysis of cystathionine β-synthase: an enzyme involved in the reverse transsulfuration pathway of Bacillus anthracis.Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria.Chemical Biology of H2S Signaling through Persulfidation.Crystallographic and mutational analyses of cystathionine β-synthase in the H2 S-synthetic gene cluster in Lactobacillus plantarum.A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis

P2860

Q24319814-6346A496-FDF9-41B8-8064-7DFFA4024BB6 Q24319930-AEE77E84-940B-458A-927A-5717FEA97BA8 Q24336765-3CEECB7F-F569-452D-AF9F-5D5239002521 Q27670452-818878F6-674B-4582-AA3B-A2424C4BD93B Q27678552-51B3D3DD-69C8-4636-AED4-DE0219CBDB32 Q27679976-D627701D-0294-4EE7-BAC0-53A45307321D Q27681439-37A7527C-8A83-43E5-ACA1-7DB6D9BB61A7 Q28541958-F2E5549D-AF81-46FC-8819-11A4D5A91F3C Q30417010-B79C2B46-266A-47BF-88E3-7C75AD2A798E Q34145385-4FCEAE5B-4326-4AB2-9D2A-79550C633104 Q34218322-1550777D-245B-4B1E-B559-D13F26CDD812 Q34757776-F5604B71-20A4-4646-AB97-80A3D598EA05 Q34774516-F50B79CF-EB03-40D7-BDEE-304CFBE0752E Q35243063-5A1324AD-5BF8-43E6-9046-B5ADD361E452 Q35289227-7A678A43-BB1D-40FF-A256-AED74C99F964 Q35353935-9A09514F-1E48-4C8B-83CB-16C4873E83D7 Q35860144-41B9D5CA-3BE3-4083-9AB1-2A96F49ABBA5 Q35862438-B45A68C2-E7A0-47C3-84E1-28BE0F41D545 Q36298369-807A7D31-1D9C-40C3-A4F0-8D881513CDA0 Q36368169-19F09513-2838-4827-A294-E7F7F27438A5 Q36448196-000D007B-5456-406A-837F-4A15551D6C16 Q36448200-004026DF-8E11-4009-92F2-B104A09C932E Q36481760-56760B51-CF1B-48E1-820E-A014B5F592FC Q36600625-719D85D7-90BA-43BC-9533-C5B23D624EAD Q36778803-1F87344B-6BDA-4EDC-B817-107F4398F26D Q37068583-EA438638-AA15-4914-8FE7-9B687BF5C7EE Q37089366-9DD56F07-332E-4D84-81DD-BA49BF7E4DA5 Q37621407-398D3115-9104-441C-B194-515C2C19746C Q37895205-8D13FADE-B4EF-49FF-BE31-141CFDA43581 Q38684460-B976BAB9-118E-4B4F-8535-D399C6BC018C Q38840287-6456B850-D36E-4B6B-B5CF-1089F3F18F24 Q41833633-3F60121B-A058-441B-B036-6E4F63369788 Q42673013-E77B2096-D4D3-42C9-BAA7-5CB327CD879A Q42691301-A4DD7E1A-21E4-40E9-B2A5-70DB0ED4E77F Q47422775-AE2867DF-1982-4B42-9990-74B20FEB792F Q47430972-9A097503-658D-4AC1-BF0C-6B4C04EDB298 Q51166550-E5B5B64A-C9D5-440B-82A1-EEA7B4961AD2 Q58695733-A0D64329-2E3C-4764-816F-D5E0623F30AB

P2860

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine -synthase

http://www.wikidata.org/entity/Q27665916

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Structural basis for substrate ...... ns in cystathionine -synthase

@ast

Structural basis for substrate ...... ns in cystathionine -synthase

@en

Structural basis for substrate ...... ns in cystathionine -synthase

@nl

type

label

Structural basis for substrate ...... ns in cystathionine -synthase

@ast

Structural basis for substrate ...... ns in cystathionine -synthase

@en

Structural basis for substrate ...... ns in cystathionine -synthase

@nl

prefLabel

Structural basis for substrate ...... ns in cystathionine -synthase

@ast

Structural basis for substrate ...... ns in cystathionine -synthase

@en

Structural basis for substrate ...... ns in cystathionine -synthase

@nl

P1433

Q27665916-23658346-3E9A-4A1A-A18E-E52835EEC4FE

P1476

Q27665916-A71D4A05-C6BB-49B1-BCC9-473C5530A5FD

P2093

Q27665916-33D14B7F-8B10-4408-8A34-6DD03B9FBADD

Q27665916-9E212C94-10D6-430A-A274-A3DD3F11D965

Q27665916-DAAD7142-9920-4867-8D80-7CAA876453B1

P2860

Q27665916-02B14E01-2794-42EC-B2A8-140460BD7068

Q27665916-0EE75A79-8274-4982-A1A1-FD5D02DDEB51

Q27665916-18328174-42EA-4F8F-9346-ED47ACE80D5E

Q27665916-2B5E16CC-8F1D-4DE8-8D4E-F694C0F4CEFD

Q27665916-2C4B9AFB-8B1C-418D-B9D0-4CABB5654C02

Q27665916-2D213F35-092E-41C8-9C5B-7D071057ABED

Q27665916-302745E6-86FF-417B-B1A4-B131B0B5E5F9

Q27665916-338B49B8-27C5-46E6-8400-C98647389081

Q27665916-370EDEA4-2452-4923-B0F8-46DCAD33BAB4

Q27665916-394AB91C-C176-4BC0-A12B-FD57FDB40C30

P304

Q27665916-7B7C01BA-E784-4782-9D59-D6884C42F7E4

P31

Q27665916-629295F3-E61E-408B-B599-8B62FBB9E90C

P356

Q27665916-9D732BC5-D64E-4D35-BC70-B423D630B269

P407

Q27665916-1531C781-C121-450B-9FF9-B5D48923EB11

P433

Q27665916-7763AB73-CA8F-4458-89D4-A19AC2160AE9

P478

Q27665916-83BFCA76-C52E-412D-8074-F3527133B0D9

P50

Q27665916-2309B69F-C61D-4F6F-90AF-30DBF418A3B9

P577

Q27665916-D11CB438-2F72-4CFE-AEA9-46EBCEFB6E63

P5875

Q27665916-6128A1E8-1FB9-471B-AC34-6D8D2BEC3231

P698

Q27665916-17A11989-01E2-4810-87EB-C328547DDDF2

P932

Q27665916-BA2E1FFF-AA72-4E5A-8064-F5413F75D163

P356

PNAS.1011448107

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Structural basis for substrate ...... cystathionine {beta}-synthase

@en

P2093

Janet L Smith

http://www.w3.org/2001/XMLSchema#string

Omer Kabil

http://www.w3.org/2001/XMLSchema#string

Ruma Banerjee

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein

Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine

Snapshot of a key intermediate in enzymatic thiamin catalysis: crystal structure of the alpha-carbanion of (alpha,beta-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis

Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers

Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme

Two structures of alliinase from Alliium sativum L.: apo form and ternary complex with aminoacrylate reaction intermediate covalently bound to the PLP cofactor

P304

20958-20963

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1011448107

http://www.w3.org/2001/XMLSchema#string

P407

P433

49

http://www.w3.org/2001/XMLSchema#string

P478

107

http://www.w3.org/2001/XMLSchema#string

P50

P577

2010-11-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

47809190

http://www.w3.org/2001/XMLSchema#string

P698

21081698

http://www.w3.org/2001/XMLSchema#string

P932

3000283

http://www.w3.org/2001/XMLSchema#string