Mechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain - sprookjes - yvandenbroek - TriplyDB

Mechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain

Mechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain

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Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation Structure of the carboxy-terminal region of a KCNH channel Mycobacterium tuberculosis RNA Polymerase-binding Protein A (RbpA) and Its Interactions with Sigma Factors Structural properties of PAS domains from the KCNH potassium channels The S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation Gating Structure of the C-terminal region of an ERG channel and functional implications The structural mechanism of KCNH-channel regulation by the eag domain.Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family.Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome.The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channel hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: a possible mechanism for long QT syndrome.C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation.Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.Alternatively Spliced Isoforms of KV10.1 Potassium Channels Modulate Channel Properties and Can Activate Cyclin-dependent Kinase in Xenopus Oocytes.The eag domain regulates hERG channel inactivation gating via a direct interaction.Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides.CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactions Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain LQT2 nonsense mutations generate trafficking defective NH2-terminally truncated channels by the reinitiation of translation.Cytoplasmic domains and voltage-dependent potassium channel gating.Insights into hERG K+ channel structure and function from NMR studies.Voltage-dependent gating of HERG potassium channels.Mechanism of electromechanical coupling in voltage-gated potassium channels.The enigmatic cytoplasmic regions of KCNH channels.Getting to the heart of hERG K(+) channel gating.Screening for Non-Pore-Binding Modulators of EAG K+ Channels.Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome.Molecular Pathophysiology of Congenital Long QT Syndrome.Development of Safe Drugs: The hERG Challenge.

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Mechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain

http://www.wikidata.org/entity/Q27666202

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2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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Mechanistic Insight into Human ...... on Structure of the EAG Domain

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Mechanistic Insight into Human ...... on Structure of the EAG Domain

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Mechanistic Insight into Human ...... on Structure of the EAG Domain

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Alexander Bowen

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Frederick W Muskett

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John S Mitcheson

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Samrat Thouta

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Steven J Thomson

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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

HERG, a human inward rectifier in the voltage-gated potassium channel family

The inward rectification mechanism of the HERG cardiac potassium channel

A family of potassium channel genes related to eag in Drosophila and mammals

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels

Structural basis for modulation and agonist specificity of HCN pacemaker channels

Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins

Structure of the redox sensor domain of Azotobacter vinelandii NifL at atomic resolution: signaling, dimerization, and mechanism

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