about
TRIM5 is an innate immune sensor for the retrovirus capsid latticeHIV type 1 Gag as a target for antiviral therapyHIV-1 capsid: the multifaceted key player in HIV-1 infectionMagic angle spinning NMR of virusesVirus maturationEbselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication.Direct and dynamic detection of HIV-1 in living cellsProtease cleavage leads to formation of mature trimer interface in HIV-1 capsidStructure of the rhesus monkey TRIM5 PRYSPRY domain, the HIV capsid recognition moduleGain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α SpecificityMature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamicsDistinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA ProteinDiscovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid ComplexesStructure and Dynamics of Full-Length HIV-1 Capsid Protein in SolutionStructure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopyCryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assemblyMonitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine seriesStructure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolutionSTRUCTURAL VIROLOGY. Conformational plasticity of a native retroviral capsid revealed by x-ray crystallographyStructure of the Dimerization Interface in the Mature HIV-1 Capsid Protein Lattice from Solid State NMR of Tubular AssembliesFitness costs of mutations at the HIV-1 capsid hexamerization interfaceEffect of Glu12-His89 Interaction on Dynamic Structures in HIV-1 p17 Matrix Protein Elucidated by NMRRhesus monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral coreAll-Atom Molecular Dynamics of Virus Capsids as Drug TargetsHelical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles.Crystal structure of an HIV assembly and maturation switch.Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids.Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α.Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly.STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.MAS NMR of HIV-1 protein assemblies.Composite Sequence-Structure Stability Models as Screening Tools for Identifying Vulnerable Targets for HIV Drug and Vaccine Development.Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments.Unusual arginine formations in protein function and assembly: rings, strings, and stacks.Design of in vitro symmetric complexes and analysis by hybrid methods reveal mechanisms of HIV capsid assemblycellPACK: a virtual mesoscope to model and visualize structural systems biology.Maturation of the HIV-1 core by a non-diffusional phase transition.HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesisIn vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Atomic-level modelling of the HIV capsid
@ast
Atomic-level modelling of the HIV capsid
@en
Atomic-level modelling of the HIV capsid
@nl
type
label
Atomic-level modelling of the HIV capsid
@ast
Atomic-level modelling of the HIV capsid
@en
Atomic-level modelling of the HIV capsid
@nl
prefLabel
Atomic-level modelling of the HIV capsid
@ast
Atomic-level modelling of the HIV capsid
@en
Atomic-level modelling of the HIV capsid
@nl
P2093
P2860
P3181
P356
P1433
P1476
Atomic-level modelling of the HIV capsid
@en
P2093
Barbie K Ganser-Pornillos
Mark Yeager
Owen Pornillos
P2860
P2888
P3181
P356
10.1038/NATURE09640
P407
P577
2011-01-20T00:00:00Z
P5875
P6179
1019638747