The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger
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Superstructure of the centromeric complex of TubZRC plasmid partitioning systemsStructural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaksThe nuclear protein Poly(ADP-ribose) polymerase 3 (AtPARP3) is required for seed storability in Arabidopsis thaliana.PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.Functional Aspects of PARP1 in DNA Repair and Transcription.Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair.PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damageThe antiproliferative effect of Moringa oleifera crude aqueous leaf extract on cancerous human alveolar epithelial cells.DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repairDisruption of PARP1 function inhibits base excision repair of a sub-set of DNA lesionsFluorescence strategies for high-throughput quantification of protein interactionsSelective Sensitization of Zinc Finger Protein Oxidation by Reactive Oxygen Species through Arsenic Binding.PARP-1 protein expression in glioblastoma multiforme.Alternative modes of binding of poly(ADP-ribose) polymerase 1 to free DNA and nucleosomesCapturing snapshots of APE1 processing DNA damage.Synthesis and characterization of DNA minor groove binding alkylating agentsFluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.Minor grove binding ligands disrupt PARP-1 activation pathways.Conformational activation of poly(ADP-ribose) polymerase-1 upon DNA binding revealed by small-angle X-ray scattering.S-nitrosation on zinc finger motif of PARP-1 as a mechanism of DNA repair inhibition by arsenite.Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response.The rise and fall of poly(ADP-ribose): An enzymatic perspective.Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival.Single nucleotide polymorphisms in DNA repair genes and putative cancer risk.Coordination of DNA single strand break repair.Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients.DNA recognition for virus assembly through multiple sequence-independent interactions with a helix-turn-helix motif.Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue.PARP-mediated repair, homologous recombination, and back-up non-homologous end joining-like repair of single-strand nicksVisualization of a DNA-PK/PARP1 complex.DNA-dependent SUMO modification of PARP-1Structural and Biochemical Characterization of Poly-ADP-ribose Polymerase from Trypanosoma bruceiPARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.
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P2860
The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger
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2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
The DNA-Binding Domain of Huma ...... through Its Second Zinc Finger
@ast
The DNA-Binding Domain of Huma ...... through Its Second Zinc Finger
@en
The DNA-Binding Domain of Huma ...... through Its Second Zinc Finger
@nl
type
label
The DNA-Binding Domain of Huma ...... through Its Second Zinc Finger
@ast
The DNA-Binding Domain of Huma ...... through Its Second Zinc Finger
@en
The DNA-Binding Domain of Huma ...... through Its Second Zinc Finger
@nl
prefLabel
The DNA-Binding Domain of Huma ...... through Its Second Zinc Finger
@ast
The DNA-Binding Domain of Huma ...... through Its Second Zinc Finger
@en
The DNA-Binding Domain of Huma ...... through Its Second Zinc Finger
@nl
P2093
P2860
P3181
P1476
The DNA-Binding Domain of Huma ...... through Its Second Zinc Finger
@en
P2093
David Neuhaus
Dominika Gruszka
Ji-Chun Yang
Paul T Cole
Sebastian Eustermann
P2860
P304
P3181
P356
10.1016/J.JMB.2011.01.034
P407
P577
2011-03-18T00:00:00Z