Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme - sprookjes - yvandenbroek - TriplyDB

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

http://www.wikidata.org/entity/Q27666879

about

Assembly of allosteric macromolecular switches: lessons from PKA Localization and quaternary structure of the PKA RI holoenzyme Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication Structure and Allostery of the PKA RII Tetrameric Holoenzyme Electrostatic Switch Function in the Mechanism of Protein Kinase A Iα Activation: Results of the Molecular Dynamics Simulation.Statistical Mechanics of Allosteric Enzymes.Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding Structural insights into mis-regulation of protein kinase A in human tumors.Membrane potential and Ca2+ concentration dependence on pressure and vasoactive agents in arterial smooth muscle: A model.An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes Evolution of the eukaryotic protein kinases as dynamic molecular switches.Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.Unidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A.Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state.Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain.A tool set to map allosteric networks through the NMR chemical shift covariance analysis.Structural Basis of Analog Specificity in PKG I and II.Molecular Simulations Reveal an Unresolved Conformation of the Type IA Protein Kinase A Regulatory Subunit and Suggest Its Role in the cAMP Regulatory Mechanism.Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα.A Gaussian network model study suggests that structural fluctuations are higher for inactive states than active states of protein kinases.Conservation of structural fluctuations in homologous protein kinases and its implications on functional sites.Role of arginine 209 in the conformational transition of the protein kinase A regulatory subunit RIα A-domain.Switching of the folding-energy landscape governs the allosteric activation of protein kinase A A FlAsH-Based Cross-Linker to Study Protein Interactions in Living Cells

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Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

http://www.wikidata.org/entity/Q27666879

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

@wuu

name

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

@ast

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

@en

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

@nl

type

label

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

@ast

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

@en

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

@nl

prefLabel

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

@ast

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

@en

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

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J.STR.2010.12.005

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P1476

Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme

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Angela J Boettcher

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Choel Kim

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Jessica Bruystens

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Jian Wu

http://www.w3.org/2001/XMLSchema#string

Jie Yang

http://www.w3.org/2001/XMLSchema#string

Juniper K Pennypacker

http://www.w3.org/2001/XMLSchema#string

Nikki Cheung

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Susan S Taylor

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P2860

Determination of domain structure of proteins from X-ray solution scattering

SuperPose: a simple server for sophisticated structural superposition

Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit

Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase

Structure and regulation of the cAMP-binding domains of Epac2

Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure

PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

Novel Isoform-Specific Interfaces Revealed by PKA RIIβ Holoenzyme Structures

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265-276

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scholarly article

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10.1016/J.STR.2010.12.005

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2

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19

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Alexandr P Kornev

Donald K Blumenthal

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2011-02-01T00:00:00Z

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49816503

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21300294

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Protein kinase, cAMP dependent, catalytic, alpha

structural biology

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3097484

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