Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins
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Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkersMolecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complexE-cadherin interactome complexity and robustness resolved by quantitative proteomicsCadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapiesA designed point mutant in Fis1 disrupts dimerization and mitochondrial fissionNeisserial Opa Protein-CEACAM Interactions: Competition for Receptors as a Means of Bacterial Invasion and Pathogenesis.The impact of Thr91 mutation on c-Src resistance to UM-164: molecular dynamics study revealed a new opportunity for drug design.Three-dimensional domain swapping in the protein structure space.Cadherin flexibility provides a key difference between desmosomes and adherens junctions.Two glycosylation sites in H5N1 influenza virus hemagglutinin that affect binding preference by computer-based analysis.Structural and energetic determinants of adhesive binding specificity in type I cadherinsIdeal, catch, and slip bonds in cadherin adhesionResolving the molecular mechanism of cadherin catch bond formation.Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions.A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion.Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery.Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring.Thinking outside the cell: how cadherins drive adhesion.Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cellsMolecular determinants of cadherin ideal bond formation: Conformation-dependent unbinding on a multidimensional landscape.Cadherin-dependent mechanotransduction depends on ligand identity but not affinity.Tuning the kinetics of cadherin adhesionMechanism of E-cadherin dimerization probed by NMR relaxation dispersion.Molecular basis of sidekick-mediated cell-cell adhesion and specificityDiscovery and development of N-cadherin antagonists.Adherens junction assembly.Cadherin recognition and adhesion.Role of cadherin-11 in synovial joint formation and rheumatoid arthritis pathology.Exploration of Structural and Functional Variations Owing to Point Mutations in α-NAGA.The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA.The X-ray structure of human P-cadherin EC1-EC2 in a closed conformation provides insight into the type I cadherin dimerization pathway.Epithelial-mesenchymal transition and nuclear β-catenin induced by conditional intestinal disruption of Cdh1 with Apc is E-cadherin EC1 domain dependent.Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants Through Conformational Sampling Approach.Biophysical Tools to Study Cellular Mechanotransduction.Zebrafish calsyntenins mediate homophilic adhesion through their amino-terminal cadherin repeats.Arrhythmogenic cardiomyopathy related DSG2 mutations affect desmosomal cadherin binding kinetics.Identification of four novel PCDH19 Mutations and prediction of their functional impact.Emergence of a Promising Lead Compound in the Treatment of Triple Negative Breast Cancer: An Insight into Conformational Features and Ligand Binding Landscape of c-Src Protein with UM-164.Structural distortions due to missense mutations in human formylglycine-generating enzyme leading to multiple sulfatase deficiency.A potential new, stable state of the E-cadherin strand-swapped dimer in solution.
P2860
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P2860
Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Molecular design principles un ...... sive dimerization of cadherins
@ast
Molecular design principles un ...... sive dimerization of cadherins
@en
Molecular design principles un ...... sive dimerization of cadherins
@nl
type
label
Molecular design principles un ...... sive dimerization of cadherins
@ast
Molecular design principles un ...... sive dimerization of cadherins
@en
Molecular design principles un ...... sive dimerization of cadherins
@nl
prefLabel
Molecular design principles un ...... sive dimerization of cadherins
@ast
Molecular design principles un ...... sive dimerization of cadherins
@en
Molecular design principles un ...... sive dimerization of cadherins
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Molecular design principles un ...... sive dimerization of cadherins
@en
P2093
Fabiana Bahna
Goran Ahlsen
Jeremie Vendome
Shoshana Posy
P2860
P2888
P304
P3181
P356
10.1038/NSMB.2051
P577
2011-06-01T00:00:00Z
P5875
P6179
1050410009