Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms
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tRNA binding, structure, and localization of the human interferon-induced protein IFIT5Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteinsThe TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteinsEvolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammalsBroad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5Crystal structure and nucleotide selectivity of human IFIT5/ISG58Interferon-induced genes of the expanded IFIT family show conserved antiviral activities in non-mammalian speciesMicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2.Interferon-induced Ifit proteins: their role in viral pathogenesisCentral role of ULK1 in type I interferon signalingCrystal structure of IFIT2 (ISG54) predicts functional properties of IFITs.A death-promoting role for ISG54/IFIT2Rational design of a flavivirus vaccine by abolishing viral RNA 2'-O methylation.Ifit1 inhibits Japanese encephalitis virus replication through binding to 5' capped 2'-O unmethylated RNA.Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins.Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs.The broad-spectrum antiviral functions of IFIT and IFITM proteins.Sensing microbial RNA in the cytosol.IFIT1: A dual sensor and effector molecule that detects non-2'-O methylated viral RNA and inhibits its translation.Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylationSequence-Specific Sensing of Nucleic Acids.Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.Identification of a de novo variant in CHUK in a patient with an EEC/AEC syndrome-like phenotype and hypogammaglobulinemia.Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic Candida albicans Infection.
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P2860
Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Crystal structure of ISG54 rev ...... otential functional mechanisms
@ast
Crystal structure of ISG54 rev ...... otential functional mechanisms
@en
Crystal structure of ISG54 rev ...... otential functional mechanisms
@nl
type
label
Crystal structure of ISG54 rev ...... otential functional mechanisms
@ast
Crystal structure of ISG54 rev ...... otential functional mechanisms
@en
Crystal structure of ISG54 rev ...... otential functional mechanisms
@nl
prefLabel
Crystal structure of ISG54 rev ...... otential functional mechanisms
@ast
Crystal structure of ISG54 rev ...... otential functional mechanisms
@en
Crystal structure of ISG54 rev ...... otential functional mechanisms
@nl
P2093
P2860
P3181
P356
P1433
P1476
Crystal structure of ISG54 rev ...... otential functional mechanisms
@en
P2093
Danying Chen
Haiwei Chen
Hongbing Shu
Huanhuan Liang
Joy Fleming
Yingfang Liu
Zhenlin Yang
P2860
P2888
P304
P3181
P356
10.1038/CR.2012.111
P577
2012-09-01T00:00:00Z
P5875
P6179
1049792228