Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms - sprookjes - yvandenbroek - TriplyDB

Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms

Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms

http://www.wikidata.org/entity/Q27670887

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tRNA binding, structure, and localization of the human interferon-induced protein IFIT5 Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5 Crystal structure and nucleotide selectivity of human IFIT5/ISG58 Interferon-induced genes of the expanded IFIT family show conserved antiviral activities in non-mammalian species MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2.Interferon-induced Ifit proteins: their role in viral pathogenesis Central role of ULK1 in type I interferon signaling Crystal structure of IFIT2 (ISG54) predicts functional properties of IFITs.A death-promoting role for ISG54/IFIT2 Rational design of a flavivirus vaccine by abolishing viral RNA 2'-O methylation.Ifit1 inhibits Japanese encephalitis virus replication through binding to 5' capped 2'-O unmethylated RNA.Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins.Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs.The broad-spectrum antiviral functions of IFIT and IFITM proteins.Sensing microbial RNA in the cytosol.IFIT1: A dual sensor and effector molecule that detects non-2'-O methylated viral RNA and inhibits its translation.Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylation Sequence-Specific Sensing of Nucleic Acids.Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.Identification of a de novo variant in CHUK in a patient with an EEC/AEC syndrome-like phenotype and hypogammaglobulinemia.Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic Candida albicans Infection.

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Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms

http://www.wikidata.org/entity/Q27670887

description

2012 nî lūn-bûn

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Crystal structure of ISG54 rev ...... otential functional mechanisms

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Crystal structure of ISG54 rev ...... otential functional mechanisms

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Crystal structure of ISG54 rev ...... otential functional mechanisms

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Crystal structure of ISG54 rev ...... otential functional mechanisms

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Crystal structure of ISG54 rev ...... otential functional mechanisms

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Danying Chen

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Haiwei Chen

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Hongbing Shu

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Huanhuan Liang

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Joy Fleming

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Qian Zhou

http://www.w3.org/2001/XMLSchema#string

Wen Ye

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Ying Li

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Yingfang Liu

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Zhenlin Yang

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P2860

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA

The interferon stimulated gene 54 promotes apoptosis

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Characterization of the interaction between the interferon-induced protein P56 and the Int6 protein encoded by a locus of insertion of the mouse mammary tumor virus.

A new pathway of translational regulation mediated by eukaryotic initiation factor 3

ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins

Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA

Ligand binding by TPR domains

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes

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10.1038/CR.2012.111

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