Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
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A Naturally Variable Residue in the S1 Subsite of M1 Family Aminopeptidases Modulates Catalytic Properties and Promotes Functional SpecializationX-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparumThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsIdentification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual ScreeningA Multilayer Network Approach for Guiding Drug Repositioning in Neglected DiseasesAminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development.Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.Antiparasitic chemotherapy: from genomes to mechanisms.Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.Engagement of the S1, S1' and S2' subsites drives efficient catalysis of peptide bond hydrolysis by the M1-family aminopeptidase from Plasmodium falciparum.The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.New approaches for dissecting protease functions to improve probe development and drug discoveryIdentification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug developmentThe antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.Chemical and genetic exploration of jasmonate biosynthesis and signaling paths.From crystal to compound: structure-based antimalarial drug discovery.A novel flow cytometric application discriminates among the effects of chemical inhibitors on various phases of Babesia divergens intraerythrocytic cycle.M1 aminopeptidases as drug targets: broad applications or therapeutic niche?Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation.Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases.Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation in Trypanosoma brucei.Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.Modeling of human M1 aminopeptidases for in silico screening of potential Plasmodium falciparum alanine aminopeptidase (PfA-M1) specific inhibitors.Sitagliptin does not inhibit the M1 alanyl aminopeptidase from Plasmodium falciparum.Two cap residues in the S1 subsite of a Plasmodium falciparum M1-family aminopeptidase promote broad specificity and enhance catalysis.Metallopeptidases of Toxoplasma gondii: in silico identification and gene expression.Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter
P2860
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P2860
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
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2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Bestatin-based chemical biolog ...... and M17-family aminopeptidases
@ast
Bestatin-based chemical biolog ...... and M17-family aminopeptidases
@en
Bestatin-based chemical biolog ...... and M17-family aminopeptidases
@nl
type
label
Bestatin-based chemical biolog ...... and M17-family aminopeptidases
@ast
Bestatin-based chemical biolog ...... and M17-family aminopeptidases
@en
Bestatin-based chemical biolog ...... and M17-family aminopeptidases
@nl
prefLabel
Bestatin-based chemical biolog ...... and M17-family aminopeptidases
@ast
Bestatin-based chemical biolog ...... and M17-family aminopeptidases
@en
Bestatin-based chemical biolog ...... and M17-family aminopeptidases
@nl
P2093
P2860
P50
P356
P1476
Bestatin-based chemical biolog ...... and M17-family aminopeptidases
@en
P2093
Doron C Greenbaum
Geetha Velmourougane
Gilana Reiss
Michael B Harbut
Michael Klemba
Seema Dalal
P2860
P304
P356
10.1073/PNAS.1105601108
P407
P577
2011-08-23T00:00:00Z