The structural basis of direct glucocorticoid-mediated transrepression - sprookjes - yvandenbroek - TriplyDB

The structural basis of direct glucocorticoid-mediated transrepression

The structural basis of direct glucocorticoid-mediated transrepression

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Specificity and sensitivity of glucocorticoid signaling in health and disease Chromatin architecture defines the glucocorticoid response Glucocorticoid receptor signaling in health and disease Genome-Wide Identification of Basic Helix-Loop-Helix and NF-1 Motifs Underlying GR Binding Sites in Male Rat Hippocampus.A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms.The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.Structural basis of natural promoter recognition by the retinoid X nuclear receptor.Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor.ChIP-exo signal associated with DNA-binding motifs provides insight into the genomic binding of the glucocorticoid receptor and cooperating transcription factors.Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.Corticosteroids: Mechanisms of Action in Health and Disease.Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression A trilogy of glucocorticoid receptor actions Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex.High activity of the stress promoter contributes to susceptibility to stress in the tree shrew The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals.Nuclear receptors in inflammation control: repression by GR and beyond.Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity.Context-dependent cooperation between nuclear factor κB (NF-κB) and the glucocorticoid receptor at a TNFAIP3 intronic enhancer: a mechanism to maintain negative feedback control of inflammation.Role of transcription factors in the pathogenesis of asthma and COPD.Steroid hormones in 2013: Glucocorticoids: timing, binding and environment.Glucocorticoid receptor function in health and disease.Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.Hypothalamic-Pituitary--Adrenal Axis-Feedback Control.Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma.Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence.Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.Cofactor squelching: Artifact or fact?New Insights in Glucocorticoid Receptor Signaling-More Than Just a Ligand-Binding Receptor Understanding how long-acting β2 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update.Localization and dynamics of glucocorticoid receptor at the plasma membrane of activated mast cells.Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance.Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor.Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad.A gradient of glucocorticoid sensitivity among helper T cell cytokines.Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells.

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The structural basis of direct glucocorticoid-mediated transrepression

http://www.wikidata.org/entity/Q27675411

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2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013年の論文

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2013年论文

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name

The structural basis of direct glucocorticoid-mediated transrepression

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The structural basis of direct glucocorticoid-mediated transrepression

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The structural basis of direct glucocorticoid-mediated transrepression

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The structural basis of direct glucocorticoid-mediated transrepression

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The structural basis of direct glucocorticoid-mediated transrepression

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The structural basis of direct glucocorticoid-mediated transrepression

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The structural basis of direct glucocorticoid-mediated transrepression

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The structural basis of direct glucocorticoid-mediated transrepression

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The structural basis of direct glucocorticoid-mediated transrepression

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Nature Structural & Molecular Biology

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The structural basis of direct glucocorticoid-mediated transrepression

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Christine Youn

http://www.w3.org/2001/XMLSchema#string

Eric A Ortlund

http://www.w3.org/2001/XMLSchema#string

William H Hudson

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P2860

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

Inference of macromolecular assemblies from crystalline state

Coot: model-building tools for molecular graphics

Stress and disorders of the stress system

Role of glucocorticoids and the glucocorticoid receptor in metabolism: insights from genetic manipulations.

Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound a.

Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids

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1993469

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10.1038/NSMB.2456

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1049408334

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structural biology

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3539207

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