Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold
about
Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)Directed Network Wiring Identifies a Key Protein Interaction in Embryonic Stem Cell DifferentiationConformational states and recognition of amyloidogenic peptides of human insulin-degrading enzymeDissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domainsTolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G AffitinsNanobodies and recombinant binders in cell biologyArtificial affinity proteins as ligands of immunoglobulinsMechanisms of action of therapeutic antibodies for cancerETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formationCrystal structures of a double-barrelled fluoride ion channelLibrary of binding protein scaffolds (LibBP): a computational platform for selection of binding protein scaffolds.Structural and dynamic properties that govern the stability of an engineered fibronectin type III domainMonobodies and other synthetic binding proteins for expanding protein scienceSelective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.NextGen protein design.Converting a binding protein into a biosensing conformational switch using protein fragment exchange.Structural insights for engineering binding proteins based on non-antibody scaffoldsProof of dual-topology architecture of Fluc F- channels with monobody blockers.Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold InteractionsSelection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions.High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin DomainsStreamlining the Pipeline for Generation of Recombinant Affinity Reagents by Integrating the Affinity Maturation Step.Modular protein switches derived from antibody mimetic proteins.Protein and Antibody Engineering by Phage Display.Engineered Autonomous Human Variable DomainsA Gradient of Sitewise Diversity Promotes Evolutionary Fitness for Binder Discovery in a Three-Helix Bundle Protein Scaffold.Titratable Avidity Reduction Enhances Affinity Discrimination in Mammalian Cellular Selections of Yeast-Displayed Ligands.Architecture of the fungal nuclear pore inner ring complex.Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase InterfaceMonobody-mediated alteration of enzyme specificityInhibition of RAS function through targeting an allosteric regulatory site.sNASP and ASF1A function through both competitive and compatible modes of histone binding.Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1.Designer protein delivery: From natural to engineered affinity-controlled release systems.Beyond peptides and mAbs--current status and future perspectives for biotherapeutics with novel constructs.Inhibitory effects of H-Ras/Raf-1-binding affibody molecules on synovial cell function.Optimization of a β-sheet-cap for long loop closure.Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains.Characterization of monobody scaffold interactions with ligand via force spectroscopy and steered molecular dynamics.Alternative reagents to antibodies in imaging applications.
P2860
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P2860
Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold
description
2012 nî lūn-bûn
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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Teaching an Old Scaffold New T ...... e Surfaces of the FN3 Scaffold
@ast
Teaching an Old Scaffold New T ...... e Surfaces of the FN3 Scaffold
@en
Teaching an Old Scaffold New T ...... e Surfaces of the FN3 Scaffold
@nl
type
label
Teaching an Old Scaffold New T ...... e Surfaces of the FN3 Scaffold
@ast
Teaching an Old Scaffold New T ...... e Surfaces of the FN3 Scaffold
@en
Teaching an Old Scaffold New T ...... e Surfaces of the FN3 Scaffold
@nl
prefLabel
Teaching an Old Scaffold New T ...... e Surfaces of the FN3 Scaffold
@ast
Teaching an Old Scaffold New T ...... e Surfaces of the FN3 Scaffold
@en
Teaching an Old Scaffold New T ...... e Surfaces of the FN3 Scaffold
@nl
P2093
P2860
P1476
Teaching an Old Scaffold New T ...... e Surfaces of the FN3 Scaffold
@en
P2093
Akiko Koide
Robert J Hoey
Ryan N Gilbreth
P2860
P304
P356
10.1016/J.JMB.2011.12.019
P407
P577
2012-01-13T00:00:00Z